Words similar to problem

Example sentences for: problem

How can you use “problem” in a sentence? Here are some example sentences to help you improve your vocabulary:

In general, we expect w ( d ) ≈ w neut ( d ) + w comp ( d ). However, method M1 has the problem that some of the mutations counted in x comp ( d ) may actually lead back onto the network of the reference sequence rather than onto a separate neutral network.
What a problem!
The problem is that the Clintons aren't an isolated example.
Two recently proposed algorithms seeking to address this multiple testing problem, Significance Analysis of Microarray (SAM) and Westfall and Young step-down adjusted p values, will be investigated in our study.
But to address the problem at hand: Your wife, for whatever reason, is committed to an epistolary marriage.