Words similar to problematic
Example sentences for: problematic
How can you use “problematic” in a sentence? Here are some example sentences to help you improve your vocabulary:
While this may not be problematic in an institution with an indirect rate of 25%, it is very difficult for a researcher at an institution with an indirect rate of 60% or higher to compete, as much of the budget is taken up by indirect costs.
The GO gene-association files [ 17] are potentially problematic, because they treat each GO term independently, removing the implicit parent-child relationship.
Published methods include enterobacterial repetitive intergenic consensus sequence-PCR (ERIC-PCR), and repetitive intergenic palindromic sequence-PCR (REP-PCR) [ 2 3 ] ; random amplified polymorphic DNA-PCR (RAPD-PCR) or arbitrary primed-PCR (AP-PCR) [ 4 5 ] ; and restriction fragment length polymorphism-PCR (RFLP-PCR) of the omp 2 locus [ 6 7 ] . ERIC-PCR and RAPD-PCR are both affected by assay conditions and environmental effects during the amplification process [ 8 9 10 ] . Although the results are highly reproducible within a laboratory, laboratory-to-laboratory reproducibility has been problematic and thus makes the universal application of these methods unlikely (compare [ 2 ] and [ 3 ] ). RFLP-PCR of the omp 2 locus is not constrained by issues of reproducibility and has been useful for the differentiation of Brucella species [ 6 ] and for differentiation among isolates from marine mammal hosts [ 7 ] . However, as a tool for the epidemiology of brucellosis in livestock, this technique is limited by the low rate of natural sequence divergence within the locus at the biovar level.
(Most problematic: A fictitious manservant, supposed to be a sort of African-American Everyman, contemplates assassinating Wallace.)
This is obviously problematic if duplications are to be used as indicators of potential functional changes.
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