Words similar to prfa

Example sentences for: prfa

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Mutant bacteria with a transposon insertion in prfA (DP-L1075) [ 33] adhere to the host-cell surface, and induce their own uptake into a phagocytic vacuole, presumably through low-level expression of the internalins, but cannot escape from the phagocytic vacuole into the cytoplasm.
By the same sets of criteria described above for studying the difference between wild-type and actA infections, we examined whether there were any genes reproducibly induced by cytoplasmic bacteria (wild-type or actA ) but not by the avirulent organism ( prfA ). In this dataset, no genes passed these criteria during the first 4 hours of infection.
The prfA gene codes for a transcriptional regulator, which controls the virulence genes hly, plcA, plcB, mpl and actA , as well as negatively regulating itself [ 31, 32].
Three strains of L. monocytogenes were used; wild type (10403S), a mutant for the transcriptional regulation of virulence genes, prfA (DP-L1075) [ 33], and a mutant deficient for intracellular motility, actA (DP-L1942) [ 30].
To this end, we have examined the global transcriptional response of a human intestinal epithelial cell line, Caco-2, to infection by L. monocytogenes and isogenic mutants which are disrupted in the actA or prfA gene.