Words similar to pri-mi
Example sentences for: pri-mi
How can you use “pri-mi” in a sentence? Here are some example sentences to help you improve your vocabulary:
Processing of pri-miRNA into the pre-miRNA stem-loop occurs in the nucleus, while subsequent processing of pre-miRNA into 21-22 mers is a cytoplasmic event mediated by the RNAse III enzyme Dicer [ 17 18 19 20 ] ; Dicer is also responsible for cleavage of long perfectly double-stranded RNA into 21-22 nucleotide fragments during RNA interference (RNAi) [ 2 21 ] . These latter molecules, known as silencing RNA (siRNA), bind to and trigger the degradation of perfectly homologous mRNA molecules via RISC, a double-strand RNA-induced silencing complex containing nuclease activity [ 22 23 ] .
While this work was under review, the clustering of miR-100, let-7 and miR-125 was independently reported; these researchers also provide evidence for coordinate expression of these miRNAs as a single pri-miRNA [ 45 50 ] .
Our observation that the temporal expression profile of miR-100 (Figure 5d) is similar to that described for let-7 and miR-125 (that is, expression is initiated during larval/pupal development and continues through adulthood [ 9 29 ] ) is consistent with probable coordinate expression of all three as a single pri-miRNA transcript, and may further implicate miR-100 in developmental timing.
In general, it is thought that miRNA biogenesis proceeds via intermediate precursor transcripts of more than 70 nucleotides that have the capacity to form an extended stem-loop structure (pre-miRNA), although at least some pre-miRNAs are further derived from even longer transcripts (primary miRNA transcripts, or pri-miRNAs).
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