Example sentences for: post-translational

How can you use “post-translational” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • During this transition, tightly-regulated post-translational phosphorylation-dephosphorylation events and proteasome-mediated proteolytic reactions regulate the activation and inactivation of signal transduction pathways that control chromatin condensation, nuclear membrane dissolution, microtubule nucleation, and formation of a haploid oocyte [ 8 9 10 ] . Several kinases that exert major roles during OM include maturation promoting factor (MPF) [ 9 11 ] , mitogen-activated protein kinases (MAPKs) [ 12 13 ] , and the product of the c-mos protooncogene Mos kinase [ 14 15 ] . Also, during OM oocytes undergo two highly-regulated metaphase-anaphase transitions (MAT) in which homologous chromosomes are equally and randomly segregated to an oocyte and first polar body and a subsequent division in which equational division of sister chromatids results in a haploid oocyte and a second polar body.

  • E.-coli -expressed pR has post-translational modifications, including ~4000 daltons of substituents at one or more of its three cysteines.

  • Recent work in Drosophila tissue culture has shown that endogenous Ptc and Smo proteins are differentially affected by the addition of Hh to the growth medium [ 5 ] . Ptc was destabilized, while Smo accumulated following post-translational modification.

  • Subsequent SDS-PAGE analysis of pR samples that had been stored for periods of time up to several months indicate that after sitting for several weeks in octylglucoside solution at 4°C, the largest post-translational modification on wild-type pR is eliminated - presumably hydrolysed off of the cysteine(s) - leaving only a 31,000-MW band indistinguishable from that seen for pR-TCM (data not shown).

  • The characterization of potentially altered interactions between hypophosphorylated RARα and its cofactors will provide unique insight into how post-translational modification of nuclear hormone receptors regulates repressor release, coactivator recruitment, histone acetylation, and transcriptional activation.


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