Words similar to post-transcriptional
Example sentences for: post-transcriptional
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There are a number of important features associated with this vector that are illustrated in Fig 2. This plasmid includes a unique SalI restriction endonuclease cut-site for insertion of open reading frames, followed by intron and poly- [A] addition sequences for correct post-transcriptional processing of transgenic RNA.
MMP-9 is inducible by inflammatory cytokines such as tumor necrosis factor-α and interleukin-1 [ 19, 29], and the post-transcriptional regulation in vivo remains incompletely understood.
Our collective ignorance of the totality of non-coding RNA genes was laid bare by recent work on microRNAs (miRNAs), an abundant family of 21-22 nucleotide non-coding RNAs [ 2 3 ] . The founding members of this family, lin-4 and let-7, were identified through forward analysis of extant Caenorhabditis elegans mutants [ 4 5 ] . Both of these RNAs are post-transcriptional regulators of developmental timing that function by binding to the 3' untranslated regions (3' UTRs) of target genes [ 5 6 7 8 ] . Although they were long regarded as genetic curiosities possibly specific to nematodes, let-7 was subsequently found to be broadly conserved across bilaterian evolution [ 9 ] and miRNA genes are now recognized as a pervasive and widespread feature of animal and plant genomes [ 10 11 12 13 14 15 16 ] .
Its production may be modulated at transcriptional, post-transcriptional, and post-translational levels [ 48 49 50 ] . Many of the effects observed after LPS stimulation can be attributed to subsequent production of TNF.
We anticipate that other examples of sequence motifs that are conserved in orthologs of the three dipterans and that are strongly complementary to miRNAs will be prime candidates to test as new examples of miRNA-mediated post-transcriptional gene regulation.
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