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Example sentences for: pomc
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The hypophagia of diet-induced obesity may be related to the modestly elevated hypothalamic POMC, whose product alpha-MSH is a known anorexic agent [ 20 29 ] . In turn, the induction of hypothalamic POMC by the high-fat diet might have been due in part to the elevation of leptin in diet-induced obese mice (Table I).
Thus neither adrenalectomy nor remarkable enhancement of hypothalamic POMC mRNA produced significant attenuation of the diet-induced obese phenotype.
Three micrograms of total RNA from anterior pituitary was used to measure pituitary POMC mRNA.
Adrenalectomy produced a non-significant trend toward an increase in hypothalamic POMC mRNA in sham-operated mice, but a 5-fold induction of POMC mRNA in mice on the high-fat diet (Fig.
Although the mechanisms through which adrenalectomy acts to reverse obesity is not entirely clear, it is plausible that the mechanisms entail enhanced hypothalamic POMC production [ 6 ] . Hypothalamic POMC mRNA is reduced in several forms of obesity [ 18 19 20 ] . Conversely, reversal of obese phenotypes by adrenalectomy is associated with a restoration of hypothalamic POMC mRNA tone in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the melanocortin agonist MTII (which mimics the key anti-obesity product of POMC, alpha-MSH) reduces body weight in diet-induced obesity [ 21 ] . On the other hand, the effect of diet-induced obesity on hypothalamic POMC mRNA is somewhat complex and may depend on the genetic background [ 22 23 ] , and duration of the diet [ 24 25 ] or composition [ 23 ] of the diet.
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