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Example sentences for: pomc
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Although the mechanisms through which adrenalectomy acts to reverse obesity is not entirely clear, it is plausible that the mechanisms entail enhanced hypothalamic POMC production [ 6 ] . Hypothalamic POMC mRNA is reduced in several forms of obesity [ 18 19 20 ] . Conversely, reversal of obese phenotypes by adrenalectomy is associated with a restoration of hypothalamic POMC mRNA tone in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the melanocortin agonist MTII (which mimics the key anti-obesity product of POMC, alpha-MSH) reduces body weight in diet-induced obesity [ 21 ] . On the other hand, the effect of diet-induced obesity on hypothalamic POMC mRNA is somewhat complex and may depend on the genetic background [ 22 23 ] , and duration of the diet [ 24 25 ] or composition [ 23 ] of the diet.
Although diet did not influence pituitary POMC mRNA, adrenalectomy increased pituitary POMC expression in mice on both diets (Table I).
On the other hand, using the same adrenalectomy protocol that produced a similar reduction, but not elimination, of plasma corticosterone levels, we observed a remarkable reversal of obese phenotypes in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the reduction of corticosterone by adrenalectomy in the present study was sufficient to produce elevation of pituitary POMC mRNA (as well as hypothalamic POMC mRNA), demonstrating that the reduced levels were clearly producing physiological effects.
Basal POMC is reduced, but inducible upon stress [ 16 ] . Thus, an obligatory function of LIF may be in the processing of POMC to ACTH during acute stress.
In the present study, we observed that adrenalectomy did indeed lead to a remarkable enhancement of hypothalamic POMC mRNA tone in mice made obese on a high-fat diet; surprisingly, however, adrenalectomy did not reverse diet-induced obesity.
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