Example sentences for: pomc

How can you use “pomc” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Effects of diet and adrenalectomy on pituitary POMC mRNA

  • Together these results suggest that an elevation of corticosterone is necessary for reduction in melanocortin tone during fasting and with diabetes and is sufficient to induce hypothalamic AGRP mRNA but not to reduce POMC expression.

  • On the other hand, using the same adrenalectomy protocol that produced a similar reduction, but not elimination, of plasma corticosterone levels, we observed a remarkable reversal of obese phenotypes in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the reduction of corticosterone by adrenalectomy in the present study was sufficient to produce elevation of pituitary POMC mRNA (as well as hypothalamic POMC mRNA), demonstrating that the reduced levels were clearly producing physiological effects.

  • In turn, as with fasting, the reduction of plasma leptin could be the cause of the elevation of hypothalamic AGRP and NPY mRNA, as well as the reduction of hypothalamic POMC mRNA.

  • Together with the reduction in serum corticosterone, this induction of pituitary POMC indicates that the adrenalectomy produced a physiologically significant reduction in corticosterone tone.


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