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Example sentences for: pomc
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Interestingly, at least with respect to food intake and body weight over this 48-hour period, the elevation of POMC appears to compensate for the elevation in AGRP to produce no net functional effect on body weight homeostasis in the presence of significantly elevated plasma corticosterone.
Although the mechanisms through which adrenalectomy acts to reverse obesity is not entirely clear, it is plausible that the mechanisms entail enhanced hypothalamic POMC production [ 6 ] . Hypothalamic POMC mRNA is reduced in several forms of obesity [ 18 19 20 ] . Conversely, reversal of obese phenotypes by adrenalectomy is associated with a restoration of hypothalamic POMC mRNA tone in leptin-deficient ob/ob mice [ 6 ] . Furthermore, the melanocortin agonist MTII (which mimics the key anti-obesity product of POMC, alpha-MSH) reduces body weight in diet-induced obesity [ 21 ] . On the other hand, the effect of diet-induced obesity on hypothalamic POMC mRNA is somewhat complex and may depend on the genetic background [ 22 23 ] , and duration of the diet [ 24 25 ] or composition [ 23 ] of the diet.
Basal POMC is reduced, but inducible upon stress [ 16 ] . Thus, an obligatory function of LIF may be in the processing of POMC to ACTH during acute stress.
Adrenalectomy blocked this reduction in POMC mRNA in diabetic mice whether or not they were fasted (Fig.
Third, we have demonstrated using corticosterone implants, that elevated corticosterone is sufficient to enhance hypothalamic AGRP expression, but not to reduce hypothalamic POMC mRNA.
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