Words similar to polymyxin

Example sentences for: polymyxin

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Cells at 60-70% confluence were exposed to the TransIT-LT1:DNA complex for 8 h in complete medium plus freshly added 30 mg/mL polymyxin B antibiotic [ 32].
For example, sensitivity to the antibacterial lipopeptide polymyxin B is affected by the PmrA-PmrB regulon, which mediates substitution of 4-aminoarabinose on the 4´ phosphate of lipid A [ 52 53 ] . By reducing the negative charge of lipid A, this modification decreases its electrostatic interaction with cationic peptides.
Colistin is a cationic polypeptide antibiotic of the polymyxin family that is rapidly bactericidal to Gram-negative bacteria.
Resistance to polymyxin B is also imparted by the absence or masking of critical binding sites required for polycation-mediated permeabilization of the outer membrane [ 54 ] . Thus, attachment of polymyxin B to Yersinia enterocolitica is reduced by steric hindrance generated by the size and/or branched shape of the outer core region of its LPS macromolecule [ 55 ] . Additionally, resistance to cationic peptides can be due to cytoplasmic clearance of the antimicrobial peptide by an efflux pump; e.g., Yersinia resistance to polymyxin B caused by the RosA/RosB efflux pump/potassium antiporter [ 56 ] and Neisseria gonorrhoeae resistance to protegrin PG-1 via an energy-dependent efflux system termed mtr [ 57 ] .