Words similar to poly-
Example sentences for: poly-
How can you use “poly-” in a sentence? Here are some example sentences to help you improve your vocabulary:
5, 5 mM KCl, 0.1 mM EDTA, 0.1 mM DTT, 0.7 mM CaCl 2 , 40 ng poly-(dI-dC), 12% glycerol) with a final DNA concentration of 2 nM.
Although the formation of intranuclear inclusions has not been observed in previous studies of Ras-related GTPases, it is a common feature of several neurodegenerative disorders where abnormal proteins containing poly-Gln tracts are synthesized as a result of CAG codon expansions [ 52 ] . Examples include Huntington's disease (huntingtin) [ 53 54 ] , spinocerebellar ataxia (SCA) types 1 and 3 (ataxin-1 and ataxin-3) [ 55 56 ] and dentatorubral-pallidoluysian atrophy (atrophin-1) [ 57 ] . These poly-Gln protein aggregates typically contain ubiquitin [ 58 ] and members of the Hsp70 chaperone family [ 59 ] , consistent with a proposed pathway for cellular clearance of toxic misfolded proteins.
Brains were cut using a cryostat and four to sixteen micron thick coronal sections were thaw-mounted onto either untreated or 0.05% poly-DL-ornithine (Sigma, St. Louis, MO; Catalog No.
An alternative mechanism for the formation of inclusion bodies in protein conformation disorders is suggested by a recent study showing that clearance of poly-Gln and poly-Ala inclusions is accelerated by compounds like rapamycin, which stimulate protein degradation by autophagy [ 64 ] . Along similar lines, the work of Kegel et al . [ 65 ] hints that poly-Gln huntingtin may be degraded mainly in autophagic vacuoles containing lysosomal proteases.
Again, these findings agree with recent studies of poly-Gln protein aggregates, which indicate that although ubiquitinated proteins are present in the inclusions, they are not conjugated directly to the initiating poly-Gln polypeptide [ 60 ] .
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