Words similar to phagocytes
Example sentences for: phagocytes
How can you use “phagocytes” in a sentence? Here are some example sentences to help you improve your vocabulary:
These receptors may mediate the recruitment of phagocytes to the subintima, intima or synovial fluid and could provide potential therapeutic targets.
Although direct measurements of lysosomal oxidative activity in live cells were not available before the present study, several lines of evidence did point to a regulatory mechanism in phagolysosomes or lysosomes in phagocytes during phagocytosis and oxidative burst.
There have been some reports on the expression of such receptors on T cells in synovial tissue and fluid [ 12 13 14 15 16 ] . Little is known about the expression of chemokine receptors on phagocytes in the human RA synovium.
Apart from standardized measurement of PGE-2 as a marker for disease, a biologically relevant aspect of elevated PGE-2 would be in the association with altered immune profile of mononuclear phagocytes, specifically IL10 induction.
COX-2 is an inducible enzyme upregulated in inflammatory states [ 20 21 ] . Notably, many NSCLC and what have been characterized as "premalignant" lung lesions have been shown to constitutively express the COX-2 enzyme and produce prostaglandin E-2 (PGE-2), the primary product of the COX-2 pathway [ 22 23 24 25 26 ] . Importantly, PGE-2 production by tumor cells has been linked to tumor-induced immunosuppression in NSCLC [ 2 3 4 5 ] . PGE-2 has been shown to directly suppress T cell mediated immunity, the primary effector against tumor cells, at a variety of levels [ 2 3 4 5 6 7 ] . Further, PGE-2 has been shown to induce the IL10 in mononuclear cells [ 4 5 ] . IL10 is a prominent immunosuppressive cytokine that may have a dominant role in preventing innate antitumor responses in the NSCLC environment [ 2 3 4 5 ] , [ 8 9 10 11 12 13 14 15 16 17 18 19 ] . Among myriad suppressive effects on T cells and antigen presenting cells, IL10 is known to inhibit IL12 production [ 14 15 16 17 18 ] . IL12 plays a key role in the initiation and potentiation of cellular immune responses and alteration of the IL12 producing function in circulating mononuclear phagocytes may be a critical factor in suppressed T cell immunity to NSCLC [ 27 28 ] .
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