Words similar to pfam
Example sentences for: pfam
How can you use “pfam” in a sentence? Here are some example sentences to help you improve your vocabulary:
The ThiF protein adenylates ThiS prior to sulfuration of that protein by a separate sulfurtransferase [ 23 24 ] . Pfam00899 encompasses the nucleotide binding site of ThiF.
Pfam is a large collection of multiple protein sequence alignments and Profile Hidden Markov Models covering many protein domains.
As not all proteins from the 26 genomes are included in Pfam, we then tried to assign the unclassified polytopic membrane domains to the identified Pfam families by sequence similarity matching to proteins in these families.
For computational efficiency reasons, alignments that still contained more than 600 sequences were further pruned; sequences not originating from SWISS-PROT were discarded, and sequences from certain mammals were excluded (mouse, rabbit, hamsters, goat, all primates except human), since mammals are likely to be oversampled in most Pfam families.
This requires specially prepared Pfam full alignments and profile HMMs that are created with the HMMER software as follows: