Words similar to pfd
Example sentences for: pfd
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Many surgical reports attempt to determine the best surgical treatment for PFD, yet do not address the pathophysiology.
The etiology of PFD is probably multifactorial, including a genetic predisposition to connective tissue abnormalities, vaginal childbirth with damage to the innervation of the pelvic floor muscles, estrogen deficiency, and aging effects [ 1 ] . The pelvic floor, situated at the bottom of the abdominal cavity, forms a supporting shelf for the abdominal and pelvic viscera.
Conversely, levator ani from younger symptomatic patient (age 38) exhibited hypertrophy of muscle cells, accompanied by increased cytoplasmic p27 expression and manifestation of PFD.
The primary support for the pelvic organs comes from the pelvic floor muscles [ 1 2 ] . This suggests that an alteration to the levator ani supportive function may significantly contribute to the pathogenesis of PFD [ 3 ] , which affect 5% of younger and nearly 50% of elderly women [ 2 ] . In women, the levator muscles form a horizontal shelf with an anterior midline cleft (the urogenital hiatus) through which the urethra, vagina, and rectum pass.
Some recent studies indicate that long-term continuous estrogen replacement is not beneficial, yet may worsen or induce the manifestation of PFD [ 38 39 ] , possibly through the suppression of sex steroid receptor expression in the pelvic floor.
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