Words similar to perturbations
Example sentences for: perturbations
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Based on studies involving compounds that alter microtubular kinetics and induce both cell-cycle delay and aneuploidy, several groups have proposed that temporal perturbations during mammalian oocyte maturation (OM) predispose oocytes to aneuploidy [ 3 4 5 6 ] . In addition to faulty microtubule kinetics, perturbations during OM may also stem from abnormal function of centrosomes, kinetochores, spindle checkpoints proteins, the anaphase-promoting complex (APC), the securin-separin-cohesion complex proteins, and the proteasome [ 7 ] .
Perturbations in CD8 +T-cell maturation have been shown for HIV-specific CD8 +T cells, in which there is an accumulation of preterminally differentiated CD45RA -CD62L -CD8 +T cells [ 12 16 ] , and such a lack of differentiation may result in functional or homing defects.
Nic96p and Nup170p are two of the most abundant nucleoporins [ 5 31 ] , the characterized nic96 and nup170 mutants do not result in gross morphological NPC perturbations (e.g.
It has been shown that in Paget's disease of bone, a condition characterised by a localised upregulation of bone turnover, there is a significant increase in the ratio between the native peptide form of CTX (α L) and the age-modified forms (β L, D-isoaspartyl peptide and α D) [ 9 ] . The use of CTX ratios may thus be indicative of the significant decrease in the residence time and therefore the average age of the resorbed bone collagen type I fragments in Pagetic patients [ 9 ] . This indicates that perturbations in the normally well-regulated process of bone turnover can result in changes in the half-life of collagen type I within the bone matrix.
We reasoned that peripheral blood cells may serve as a surrogate tissue since VEGF receptors are expressed in certain blood cell types such as monocytes and platelets [ 11 12 ] and thus signal transduction in those cells may be directly impacted by SU5416; also, gene expression changes in blood cells caused indirectly as a result of therapy-induced perturbations might also be detected in this approach.
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