Words similar to peroxynitrite

Example sentences for: peroxynitrite

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The first proposes that the mutated SOD1 interacts with NO to produce peroxynitrite (ONOO -), which damages proteins by modifying tyrosine to nitrotyrosine residues [ 42 43 44 ] . The second postulates that the mutant SOD1 possesses an enhanced peroxidase activity, which causes oxidative modification of nucleic acids, proteins and lipids [ 45 46 47 ] . Both of these activities require copper at the active center of SOD1.
Nitration of tyrosine residues is used as an index of peroxynitrite formation but it is not specific [ 13 ] . However, the purpose of using peroxynitrite in this study was to address the effects of a potent oxidant and not to evaluate the role of peroxynitrite in pathological states.
To eliminate the excess of H 2 O 2 , the peroxynitrite solution was filtered in a column containing MnO 2 (4 g).
Peroxynitrite was synthesized as previously described [ 14 ] . Briefly, solutions of (a) 0.7 M NaNO 2 , 0.7 M H 2 O 2 and (b) 0.6 M HCl, were pumped using a syringe infusion pump (Harvard Apparatus, South Natick, MA) at 25 ml/min, into a Y-junction and mixed in a 2 mm-diameter by 0.5 cm silica tube.
Peroxynitrite (300 μM) exposure reduced cell number (MTT assay) that was not significantly altered by antioxidant therapy in either AGS or IEC-18 cell types (Tables 2and 3).