Words similar to peroxisomal
Example sentences for: peroxisomal
How can you use “peroxisomal” in a sentence? Here are some example sentences to help you improve your vocabulary:
The action is mediated by specific nuclear receptor proteins, which belong to a superfamily of ligand-modulated transcription factors that regulate homeostasis, reproduction, development, and differentiation [ 87 ] . This family includes receptors for steroid hormones, thyroid hormones, hormonal forms of vitamin A and D, peroxisomal activators, and ecdysone [ 88 ] . Nuclear hormone receptors are ligand-dependent transcription factors that regulate genes critical to such biological processes as development, reproduction, and homeostasis.
Peroxisomes shorten chains of very long fatty acids, unsaturated fatty acids and branched fatty acids by β-oxidation [ 60 61 ] . They play critical roles in synthesis of ether phospholipids and cholesterol [ 62 63 ] . Peroxisomal abundance is associated with high membrane demand such as myelination in the central nervous system [ 64 65 ] and peroxisome diseases result in defective myelination [ 66 ] . Because the outer mitochondrial membrane normally tightly wraps around mitochondria, the extension of the outer membrane during vacuolation requires new membranes.
A potential peroxisomal targeting signal is encoded on the C-terminus (SKI, aa 488-490).
These same conclusions regarding energy expenditure were reached in experiments assessing enzymatic activities, and transcriptional changes in rat liver using Northern blots, where fish oil feeding: increased palmitoyl CoA mitochondrial and peroxisomal oxidation rate; increased Cpt1, Cpt2, Δ 3, Δ 2-enoyl CoA isomerase, and Ech1 expression and activity; and decreased expression and activity of FA synthase, malic enzyme, glucose 6-phosphate dehydrogenase, and pyruvate kinase, compared to palm and/or safflower oil feeding [ 93 ] . Likewise, in rat white retroperitoneal adipose tissue, fish oil feeding also decreased Fasn expression [ 94 ] . Intriguingly, the hormone leptin, which also acts through SREBP-1 and PPARα, affected many transcripts similarly to LC-PUFA ( e.g. , leptin decreased Gpam and Apoa4 transcripts; and up regulated Ech1, mitochondrial Hmgcs2, and Cyp4a14 transcripts [ 95 ] .
Interestingly, accumulation of ceramides and cholesterol esters has been observed in ALS patients and mice [ 67 ] , which could be associated with peroxisomal proliferation.
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