Example sentences for: peroxisomal

How can you use “peroxisomal” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • A potential peroxisomal targeting signal is encoded on the C-terminus (SKI, aa 488-490).

  • These same conclusions regarding energy expenditure were reached in experiments assessing enzymatic activities, and transcriptional changes in rat liver using Northern blots, where fish oil feeding: increased palmitoyl CoA mitochondrial and peroxisomal oxidation rate; increased Cpt1, Cpt2, Δ 3, Δ 2-enoyl CoA isomerase, and Ech1 expression and activity; and decreased expression and activity of FA synthase, malic enzyme, glucose 6-phosphate dehydrogenase, and pyruvate kinase, compared to palm and/or safflower oil feeding [ 93 ] . Likewise, in rat white retroperitoneal adipose tissue, fish oil feeding also decreased Fasn expression [ 94 ] . Intriguingly, the hormone leptin, which also acts through SREBP-1 and PPARα, affected many transcripts similarly to LC-PUFA ( e.g. , leptin decreased Gpam and Apoa4 transcripts; and up regulated Ech1, mitochondrial Hmgcs2, and Cyp4a14 transcripts [ 95 ] .

  • Interestingly, accumulation of ceramides and cholesterol esters has been observed in ALS patients and mice [ 67 ] , which could be associated with peroxisomal proliferation.

  • The action is mediated by specific nuclear receptor proteins, which belong to a superfamily of ligand-modulated transcription factors that regulate homeostasis, reproduction, development, and differentiation [ 87 ] . This family includes receptors for steroid hormones, thyroid hormones, hormonal forms of vitamin A and D, peroxisomal activators, and ecdysone [ 88 ] . Nuclear hormone receptors are ligand-dependent transcription factors that regulate genes critical to such biological processes as development, reproduction, and homeostasis.

  • Peroxisomes shorten chains of very long fatty acids, unsaturated fatty acids and branched fatty acids by β-oxidation [ 60 61 ] . They play critical roles in synthesis of ether phospholipids and cholesterol [ 62 63 ] . Peroxisomal abundance is associated with high membrane demand such as myelination in the central nervous system [ 64 65 ] and peroxisome diseases result in defective myelination [ 66 ] . Because the outer mitochondrial membrane normally tightly wraps around mitochondria, the extension of the outer membrane during vacuolation requires new membranes.


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