Example sentences for: pek

How can you use “pek” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The Affymetrix website http://www.affymetrix.comwas searched using the terms 'PEK/PERK', 'GADD153' and the gene names for ER chaperones previously identified as being upregulated during an ER stress response [ 12 ] , and where they were represented by probe-sets on the U34 arrays, corresponding accession numbers were identified.

  • The first, the ER overload response, triggers the activation of the transcription factor NFkB and the subsequent upregulation of inflammatory proteins [ 13 ] . The second, the unfolded protein response (UPR) induces three divergent cellular events: (i) the activation of transcription factor ATF6 leading to the upregulation of ER chaperones such as protein disulfide isomerase, (ii) upregulation of the pro-apoptotic transcription factor GADD153 and (iii) suppression of protein synthesis via phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by pancreatic eIF2α kinase (PEK/PERK, [ 11 12 ] ). Upregulation of the ER chaperones, GADD153 and PERK in response to a toxic insult would constitute direct evidence of an ER stress response.

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