Words similar to pbpks

Example sentences for: pbpks

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Finally, to show that the validity of this approach extended beyond the anesthetics, it was also applied to toluene, a volatile solute for which detailed human PBPKs are already available.
The single most important difference between PKQuest and other PBPKs that have been applied to these solutes is the way the tissue/blood partition coefficient is handled.
Mapleson and colleagues developed a detailed anesthetic PBPK [ 7 8 9 ] and measured the relevant PBPK parameters [ 10 11 12 ] . Smith and colleagues [ 13 14 ] and Fukui and Smith [ 15 16 ] have developed complex PBPKs in which the anesthetic interacts with and modifies the organ parameters.
Some of the most comprehensive and sophisticated human PBPKs have been developed to describe the pharmacokinetics of volatile toxic solvents such as toluene [ 32 44 45 ] , styrene [ 46 47 ] , and methyl chloride [ 48 ] . The most involved models incorporate several different fat and muscle compartments with different flows and allow for changes with time in the blood flows as the subject's exercise level varies [ 45 47 48 ] . These studies have also introduced a Bayesian approach to determine the population distribution of the PBPK parameters [ 45 47 ] . PKQuest cannot complete with these PBPKs for this class of solutes.