Example sentences for: pbpks

How can you use “pbpks” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The single most important difference between PKQuest and other PBPKs that have been applied to these solutes is the way the tissue/blood partition coefficient is handled.

  • Some of the most comprehensive and sophisticated human PBPKs have been developed to describe the pharmacokinetics of volatile toxic solvents such as toluene [ 32 44 45 ] , styrene [ 46 47 ] , and methyl chloride [ 48 ] . The most involved models incorporate several different fat and muscle compartments with different flows and allow for changes with time in the blood flows as the subject's exercise level varies [ 45 47 48 ] . These studies have also introduced a Bayesian approach to determine the population distribution of the PBPK parameters [ 45 47 ] . PKQuest cannot complete with these PBPKs for this class of solutes.

  • Mapleson and colleagues developed a detailed anesthetic PBPK [ 7 8 9 ] and measured the relevant PBPK parameters [ 10 11 12 ] . Smith and colleagues [ 13 14 ] and Fukui and Smith [ 15 16 ] have developed complex PBPKs in which the anesthetic interacts with and modifies the organ parameters.

  • Finally, to show that the validity of this approach extended beyond the anesthetics, it was also applied to toluene, a volatile solute for which detailed human PBPKs are already available.

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