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Example sentences for: pbmcs
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IL-2 target genes in human PBMCs and T cells This file contains expression data for IL-2-regulated probe sets detected on the Affymetrix U95Av2 array, using samples prepared from human PBMCs and purified T cells.
Responses of PBMCs to IL-2 are complex, involving direct effects of IL-2 on gene expression by T cells, B cells and NK cells, as well as secondary effects mediated by additional cytokines and transcription factors expressed by these cells in response to IL-2.
Numerous studies have been able to show that PBMCs and B-cells in particular can have expression of viral transcript and/or antigen [ 35 36 37 38 39 40 41 ] however, other studies have been contradictory [ 40 42 ] and therefore no consensus among the observations noted.
Considering that PBMCs represent an admixture of multiple cell types, the most plausible explanation is a simple lack of shift in subcellular populations.
Similarly, of the 29 probe sets identified as meeting all 3 criteria only in pure T cells, 7 showed differences in expression with p < 0.05 in PBMCs (Table 4).