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Example sentences for: pbpk

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The impetus behind PKQuest is to try and develop a "standard" set of human PBPK parameters that can be applied in the absence of this detailed information.
The "standard human" PBPK organ weights and blood flows are listed in Table I. These are the same values that have been used previously to model the pharmacokinetics of D 2 O and ethanol [ 24 ] , toluene and the volatile anesthetics [ 25 ] , propranolol [ 26 ] and inulin and protein bound antibiotics [ 27 ] . Two different PBPK models are used.
In the first test, a continuous venous concentration curve will be generated using a known constant IV input to the PBPK model.
Mapleson and colleagues developed a detailed anesthetic PBPK [ 7 8 9 ] and measured the relevant PBPK parameters [ 10 11 12 ] . Smith and colleagues [ 13 14 ] and Fukui and Smith [ 15 16 ] have developed complex PBPKs in which the anesthetic interacts with and modifies the organ parameters.
The use of a PBPK to model pharmacokinetics requires detailed information about the blood-tissue partition coefficient for each organ.