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Example sentences for: pbpk

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Comparing the venous concentration curve determined using this r(t) with the original PBPK venous data provides a direct test of the accuracy of r(t).
The PBPK parameters used in this calculation were identical to those used for figure 2except that the portal blood flow was increased 50% because of the coincident meal [ 22 23 24 ] , the liver Vm was increased from 2.1 to 2.5 because of the induced ethanol effect [ 25 26 ] and the muscle blood flow was doubled.
Figure 4Ashows the agreement between the PBPK model and the venous plasma ethanol concentration for the IV input data.
[ 16 ] of the time course of ethanol blood levels after an IV input were used to determine the standard ethanol PBPK parameters.
[ 20 ] developed a detailed PBPK in the rat with the halothane metabolism described by a 4 parameter function that included both Michaelis-Menten and inactivation components.