Words similar to pax
Example sentences for: pax
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The reduced expression of these cytokines in Hoxa3 +/- Pax1 -/-compound mutants could be an indirect effect of defective TEC differentiation, or could be direct downstream targets since both Hoxa3 and Pax1 are expressed in fetal thymus [ 54 55 ] . Comparison of the Hoxa3 +/- Pax1 -/-phenotype with those of cytokine mutants do not reveal many similarities [ 30 46 56 57 58 59 60 61 ] , probably because of the simultaneous reductions in multiple cytokines in the Hoxa3 +/- Pax1 -/-mutants.
Thymocyte proliferation levels for all genotypes ( Hoxa3 +/-, Pax1 +/-, Pax1 -/-, and Hoxa3 +/- Pax1 -/-) were similar to wild type in all of the canonical TN1-TN4 stages (Fig.
These genes include PITX2, PITX3, PAX6, FOXC1 (previously known as FKHL7 and FREAC3), Foxc2 and FOXE3 [ 4 5 6 7 8 9 ] . Activity levels for these transcription factors normally associated with diploid gene dosage are important for normal ocular development, with heterozygosity for null mutations in most of these genes causing anterior segment dysgenesis.
In the hippocampus, dietary LC-PUFA activated a different set of transcription factors than observed in the liver, including: nuclear factor of κ light chain gene enhancer in B cells 1 p105 (Nfkb1); nescient helix loop helix 1 (Nhlh1); E2F transcription factor 3 (E2f3); basic transcription factor 3 (Btf3); inhibitor of DNA binding 1 (Idb1); D site albumin promoter binding protein (Dbp); paired box gene 9 (Pax9); and the ELK1 member of the ETS oncogene family.
We compared fetal and adult wild type mice with Hoxa3,Pax1 compound mutants [ 29 34 ] . We also assayed Rag1 -/-mice, which have defects in TEC development due to arrested thymocyte maturation at the TN3 stage [ 35 ] . We found stage-specific differences in proliferation levels between fetal and adult wild type thymocytes.
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