Words similar to pac
Example sentences for: pac
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Initially, the cytogenetic map position of a total of 18 BAC/PAC probes were comparatively mapped using fluorescence in situ hybridization (FISH) (data not shown).
Genetic linkage studies have identified five potential RD loci located on chromosomes 1 [ 1 2 ] , 2 [ 3 4 ] , 6 [ 5 6 7 8 9 ] , 15 [ 7 10 ] and 18 [ 11 ] . The linkage to 6p has been the most often reproduced in independent samples with five studies showing peaks of linkage to different regional marker sets [ 5 6 7 8 9 ] . We recently constructed a BAC/PAC contig of the 6p RD locus [ 12 ] and identified the precise location and order of 29 short tandem repeat (STR) markers spanning this region [ 13 ] . A subsequent study with this new marker panel identified a peak of transmission disequilibrium at marker JA04 (G72384) [ 14 ] .
Just as McCartney started rumors of his death by appearing on the Abbey Road cover without shoes and on Sergeant Pepper wearing an armband marked "OPD" (alleged to mean Officially Pronounced Dead), so did 2Pac, on his new album, slyly adopt the name "Makaveli"--like Machiavelli, who, according to 2Pac's rapping confrere Chuck D, faked his own death to fool his enemies--and pose on the cover in a crucifixion pose, suggesting he intended a resurrection.
Probes were selected that flank known sites of genomic rearrangement based upon previous yeast artificial chromosome (YAC) and BAC/PAC mapping studies, together with the human sequence map available from the University of California at Santa Cruz (UCSC) Genome Browser [ 11 12 13 14 15 ] . Probes flanking the Prader-Willi/Angelman syndrome breakpoints, in addition to a characterized inv dup(15) rearrangement were selected to test the possibility that the pericentric inversion evolutionary breakpoint corresponded to a site of known human genomic instability (Figure 1).
Finally the 5' arm of homology was provided by a 4.5 kb Xho I fragment of Hnf3 α genomic DNA that was introduced into a unique Pac1 site (blunt) in the preceding plasmid.
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