Words similar to paa
Example sentences for: paa
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Recombinant viruses were successfully obtained for all pols except wild type HSV-1 SC16 and the low error rate or antimutator HSV-1 PAA r5 [ 10 ] . The pol -recombinant viruses were plaque-purified and the pol genes completely sequenced along with those of their parental viruses to confirm the recombination event.
This observation is consistent with the recent report of high mutation frequency within the SupF gene upon replication by PAA r5 [ 13 ] .
The control viruses, HSV-2 6757 and HSV-1 PAA r5, demonstrated mutator or antimutator phenotypes, respectively, in the tk mutagenesis assay, but not in the non-HSV DNA mutagenesis assay.
HSV-2 pol (SB5, 83D, 6652 and 6757 described in [ 21 ] ) or HSV-1 pol (SC16 and PAA r5) coding regions were co-transfected with replication defective HP66 viral DNA containing a LacZ insertion within pol [ 17 ] into Vero cells to generate recombinant viruses.
[ 13 ] , PAA r5 showed a minor increase in mutation frequency, compared with wild type HSV-1 and HSV-2 (Table 2).