Words similar to p-m
Example sentences for: p-m
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Homology models [ 3 4 ] of the M1-P-M2 portion of Kir's have been developed using the backbone structure of KcsA.
Likewise, the hypothesis that KirBac evolved after transfer of a eukaryotic Kir to a bacteria is inconsistent with several findings: 1) all eukaryotic Kir's are more closely related to each other than to any KirBac, 2) the P-M2 region of KirBac's is more similar to that of some other bacterial K +channels than it is to that of eukaryotic Kir's, and 3) the M1-P-M2 region of eukaryotic Kir's have numerous features that occur in no other K +channels, including KirBac.
The intermediate nature of the KirBac P-M2 region between sequences of the eukaryotic Kir family and several other K +channel families can be analyzed several different ways.
1 sequence, include in sequential order: 1) A DxxTTxxDxxWR motif immediately preceding M1, 2) a highly conserved tryptophan in M1, 3) an insertion in the M1-P loop that contains a CVxx (V or I) motif, 4) the absence of an aromatic residue at the first 'aromatic cuff position [ 2 ] in the P segment helix, 5) a glutamine near the end of the P helix, 6) the absence of an aspartate at the end of the P segment signature sequence (TVGYGD) and a RxxTxxCP motif in the P-M2 loop that is two residues longer than in most other K +channels, 7) a glutamine in the first part of S6, and 8) a hydrophilic residue (Asn, Asp, or Glu) near the mid region of S6 that when negatively charged is involved in blockade of some Kir's by Mg 2+ [ 9 ] . Fig.
74 [ 7 ] was also used to make multisequence alignments of the M1-P-M2 region for members of each Kir subfamily plus the other sequences illustrated in Fig.
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