Words similar to osteopontin
Example sentences for: osteopontin
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Binding involves a family of adhesins that interact with extracellular matrix components, and these adhesins have been termed microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) [ 1 ] . Specific MSCRAMMs are responsible for localization of S. aureus to particular tissues, and include fibronectin-binding proteins (FnBPs) [ 2 3 ] , fibrinogen-binding proteins [ 4 5 6 ] , elastin-binding adhesin [ 7 ] collagen-binding adhesion [ 8 ] , and a broad-specificity adhesin (MAP) that facilitates low-affinity binding of S. aureus to several proteins, including osteopontin, collagen, bone sialoprotein, fibronectin, fibrinogen, and vitronectin [ 9 ] . S. aureus can utilize MSCRAMMs to adhere directly to cells or can attach to cells through the use of bridging ligands such as Hsp60 which has an affinity for both MSCRAMMs and the β 1 -integrin host cell receptor [ 10 11 ] . Interaction of S. aureus with host cells via MSCRAMMs can induce signal transduction, tyrosine kinase activity, and cytoskeletal rearrangement [ 12 ] .
FFPE = formalin-fixed, paraffin-embedded; H&E = hematoxylin and eosin; IHC = immunohistochemistry; LCM = laser capture microdissection; OPN = osteopontin; PBS = phosphate-buffered saline; PCR = polymerase chain reaction; qPCR = real-time, quantitative PCR; RT = reverse transcriptase; TSP-1 = thrombospondin-1; TYRP-1 = tyrosinase-related protein-1.
Initial comparative gene expression analysis of the two clones revealed the secreted, integrin-binding protein osteopontin (OPN) [ 3 ] to be significantly increased in the metastatic M-4A4 cell line.
Much of this information comes from animal cells and embryos, but the addition of BMP2 to cultured postnatal human bone marrow `preosteoblastic' cells in the presence of β-glycerophosphate and ascorbic acid increases the gene message and protein production of AP, osteopontin, bone sialoprotein, osteocalcin, and α-1 collagen [ 33].
These included the obvious - MCAM (melanoma cell adhesion molecule) - but also ATP1B2 (ATPase, Na +/K +transporting, beta 2 polypeptide, which is believed to function in neuron-astrocyte adhesion [ 29, 30]), THBS (thrombospondin, an adhesion molecule involved in blood clotting), OPN (osteopontin, which promotes osteoclast adhesion [ 31]) and OSF2 (osteoblast-specific factor 2, a human homolog of the insect protein fasciclin thought to have a role in bone adhesion [ 32]).
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