Words similar to oncoproteins

Example sentences for: oncoproteins

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Molecular modeling has shown that this domain contains two zinc finger-like motifs connected through linking C 3 HC 4 regions [ 18 ] . Naturally occurring splice variants of the gene suggest at least two transcription initiation points above and below the coding region for the RING domain [ 19 ] . Truncation studies have shown that the RING domain may function in direct protein binding of ER-α, ATF1, and BARD1, a ubiquitin ligase [ 20 21 22 ] . While zinc RING domains are common motifs in several protein families such as oncoproteins and regulatory proteins, the actual function of the domain differs among these proteins.
For example, the number of epitopes recognized by G3-245 mAb may be reduced if tumor cells express viral oncoproteins that bind and inactivate Rb [ 22 ] .
In support of this notion, the p27 protein has been identified as a target of viral oncoproteins [ 5 6 ] . However, unlike traditional tumor suppressors, the p27 gene rarely shows homozygous inactivation in cancer cells [ 7 8 9 ] , a finding that points towards alternative mechanisms of p27 inactivation.