Words similar to oncogenic
Example sentences for: oncogenic
How can you use “oncogenic” in a sentence? Here are some example sentences to help you improve your vocabulary:
This oncogenic mutation has been found in human basal cell carcinoma [ 3 ] and the correspondingly mutated protein is capable of ligand-independent activation of the Hh pathway in cell-culture assays [ 11 ] . A kinetic and saturation binding assay with Smo act-containing membranes showed that this mutant protein binds the Hh agonist with an affinity identical to that of Smo wt(data not shown).
The CD98 molecule is also widely expressed on rapidly growing non-hematopoietic cells, where it may modulate oncogenic transformation [ 10 11 ] , metal ion transport [ 12 13 ] , cell fusion [ 14 15 ] , and amino acid transport [ 16 17 18 19 ] . CD98 is also expressed on normal proliferating tissue such as the basal layer of squamous epithelia [ 20 ] and on cells having secretion or transport functions [ 21 ] . Understanding of the role of CD98 in amino acid transport has been greatly enhanced with the recent cloning and characterization of multiple CD98 light chains.
This, together with other studies, strongly suggests that BP1 has oncogenic properties, making it a new potential target in breast tumors, especially the difficult-to-treat ER-negative tumors.
These non-physiologic RSS are important because of their potential involvement in oncogenic chromosomal translocation and receptor editing, a process that alters the specificity of autoreactive receptors.
STAT1, another signaling intermediate in the IL-6 pathway, has been observed to be activated in non-tumorigenic cells, and may function as a "check" for STAT3 phosphorylation, a possible oncogenic event [ 30 31 ] . We are investigating whether or not STAT1 is phosphorylated by JAK2 in NRP-152 cells, and whether STAT1 phosphorylation is required for the survival of NRP-152 cells.
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