Words similar to oncogenic
Example sentences for: oncogenic
How can you use “oncogenic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Because locally elevated TGF-β levels could select for TGF-β-resistant cells, and because TGF-βs can have oncogenic effects on the stroma, it may actually be important for the safety profile of chemopreventive agents to demonstrate that they do not increase TGF-β levels in the at-risk breast.
This extraordinary plasticity has a price: V(D)J recombination can produce self-reactive receptors leading to autoimmune disease [ 38, 39] and may err to create oncogenic chromosomal translocations [ 40].
The CD98 molecule is also widely expressed on rapidly growing non-hematopoietic cells, where it may modulate oncogenic transformation [ 10 11 ] , metal ion transport [ 12 13 ] , cell fusion [ 14 15 ] , and amino acid transport [ 16 17 18 19 ] . CD98 is also expressed on normal proliferating tissue such as the basal layer of squamous epithelia [ 20 ] and on cells having secretion or transport functions [ 21 ] . Understanding of the role of CD98 in amino acid transport has been greatly enhanced with the recent cloning and characterization of multiple CD98 light chains.
These proteins could have a potentially important role in the regulation of cell growth, as TAX1BP, CREB3 and TARBP possess anti-apoptotic, tumor suppressor and oncogenic activities [ 23, 24, 25], respectively.
Our previous studies showed that BP1 is also expressed in leukemia and has characteristics of an oncogene: in acute myeloid leukemia, BP1 is highly expressed in the bone marrow of 63% of patients overall, with a preponderance of expression in pediatric patients [ 11 ] . When overexpressed in a leukemia cell line (K562), BP1 increased the ability of cells to grow in soft agar, an indicator of leukemogenic potential, up to 45-fold [ 11 ] . Consistent with a possible oncogenic role for BP1 in breast cancer was the observation that its expression was correlated with the ability of breast cancer cell lines to cause mammary tumors in mice.
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