Words similar to oncogenic
Example sentences for: oncogenic
How can you use “oncogenic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Our previous studies showed that BP1 is also expressed in leukemia and has characteristics of an oncogene: in acute myeloid leukemia, BP1 is highly expressed in the bone marrow of 63% of patients overall, with a preponderance of expression in pediatric patients [ 11 ] . When overexpressed in a leukemia cell line (K562), BP1 increased the ability of cells to grow in soft agar, an indicator of leukemogenic potential, up to 45-fold [ 11 ] . Consistent with a possible oncogenic role for BP1 in breast cancer was the observation that its expression was correlated with the ability of breast cancer cell lines to cause mammary tumors in mice.
This oncogenic mutation has been found in human basal cell carcinoma [ 3 ] and the correspondingly mutated protein is capable of ligand-independent activation of the Hh pathway in cell-culture assays [ 11 ] . A kinetic and saturation binding assay with Smo act-containing membranes showed that this mutant protein binds the Hh agonist with an affinity identical to that of Smo wt(data not shown).
This extraordinary plasticity has a price: V(D)J recombination can produce self-reactive receptors leading to autoimmune disease [ 38, 39] and may err to create oncogenic chromosomal translocations [ 40].
Because locally elevated TGF-β levels could select for TGF-β-resistant cells, and because TGF-βs can have oncogenic effects on the stroma, it may actually be important for the safety profile of chemopreventive agents to demonstrate that they do not increase TGF-β levels in the at-risk breast.
These proteins could have a potentially important role in the regulation of cell growth, as TAX1BP, CREB3 and TARBP possess anti-apoptotic, tumor suppressor and oncogenic activities [ 23, 24, 25], respectively.
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