Words similar to oncogenic
Example sentences for: oncogenic
How can you use “oncogenic” in a sentence? Here are some example sentences to help you improve your vocabulary:
STAT1, another signaling intermediate in the IL-6 pathway, has been observed to be activated in non-tumorigenic cells, and may function as a "check" for STAT3 phosphorylation, a possible oncogenic event [ 30 31 ] . We are investigating whether or not STAT1 is phosphorylated by JAK2 in NRP-152 cells, and whether STAT1 phosphorylation is required for the survival of NRP-152 cells.
These non-physiologic RSS are important because of their potential involvement in oncogenic chromosomal translocation and receptor editing, a process that alters the specificity of autoreactive receptors.
This extraordinary plasticity has a price: V(D)J recombination can produce self-reactive receptors leading to autoimmune disease [ 38, 39] and may err to create oncogenic chromosomal translocations [ 40].
Constitutive membrane localization of AKT leads to its deregulated activation and can induce oncogenic transformation [ 8, 9].
Our previous studies showed that BP1 is also expressed in leukemia and has characteristics of an oncogene: in acute myeloid leukemia, BP1 is highly expressed in the bone marrow of 63% of patients overall, with a preponderance of expression in pediatric patients [ 11 ] . When overexpressed in a leukemia cell line (K562), BP1 increased the ability of cells to grow in soft agar, an indicator of leukemogenic potential, up to 45-fold [ 11 ] . Consistent with a possible oncogenic role for BP1 in breast cancer was the observation that its expression was correlated with the ability of breast cancer cell lines to cause mammary tumors in mice.
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