Words similar to oncogenes
Example sentences for: oncogenes
How can you use “oncogenes” in a sentence? Here are some example sentences to help you improve your vocabulary:
The cell surface expressed integrins can control this process by physically interacting with the extracellular matrix proteins and other cell surface proteins on endothelial cells lining the blood vessel wall [ 1 ] . These integrins signal adhesion and migration by communicating with several tyrosine kinases inside the cell, including the Focal Adhesion Kinase (FAK) and Src family kinases [ 1 2 ] . Src kinases control the activation of FAK, as well as the tyrosine phosphorylation of critical substrates that regulate adhesion and migration [ 3 ] . Indeed, colon cancer cells with high metastatic potential have elevated levels of Src activity or activating mutations in the Src gene [ 4 5 ] . One Src substrate that is involved in regulating an important signaling node in this process is the adaptor protein p130 cas (Cas) [ 6 7 8 9 10 ] . Cas appears to play a central role in the transformation process by several oncogenes including ras, ornithine decarboxylase (ODC), v-Src, v-crk, and Bcr-Abl, as these tumors all have elevated levels of tyrosine phosphorylated Cas [ 6 11 12 13 ] . Cells from mice that lack Cas have much reduced migration and are resistant to transformation by v-Src, while expression of Cas anti-sense RNA in cells transformed with ras, v-Src or ODC result in reversion of the transformed phenotype [ 11 14 15 ] . Furthermore, increased expression of Cas can rescue cell migration and adhesion in cells expressing the tumor suppressor PTEN, and can enhance cell migration and adhesion in normal cells, with a major role being played by the substrate domain [ 16 17 ] .
These include DNA damage caused by Ionizing Radiation and genotoxic agents [ 1], by expression of activated oncogenes such as ras or myc [ 2], or during progression of primary cells to senescence [ 3].
Numerous reports have described the correlation between amplification of oncogenes and its impact on the course of breast cancer disease [ 4 5 6 7 ] , [ 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 ] . In a meta-analysis in which 29 studies were evaluated [ 33 ] , c- myc amplification exhibited significant but weak associations with tumour grade, lymph node metastasis, negative progesterone receptor status and postmenopausal status.
In the present study, simultaneous amplification of both oncogenes was observed in 12.
Based on a series of unselected cases, in the present study we examined the possible influence of the amplification of the oncogenes c- myc and HER-2 / neu on disease-free survival (DFS) and overall survival (OS).
Loading...