Words similar to oncogene
Example sentences for: oncogene
How can you use “oncogene” in a sentence? Here are some example sentences to help you improve your vocabulary:
Some studies claimed that HER-2 / neu status was an independent predictive factor in the case of breast cancer, whereas other studies could not confirm this [ 6 14 16 19 29 30 ] . It is certainly of great interest to the clinician that only two out of five studies including more than 100 patients and with a follow-up period of at least 3 years attributed some prognostic value to HER-2 / neu amplification among patients with NNBC [ 6 7 16 19 28 ] . Almost all of the studies that dealt with HER-2 / neu status and DFS, as well as OS, showed no benefit of this oncogene in the prognosis of NNBC patients.
The protein product of the mdm2 oncogene is over-expressed in a considerable number of tumors [ 27 ] . This protein is a pivotal negative regulator of p53 [ 27 ] ; it interacts with the P53 protein masking its transcriptional domain and accelerating its proteasomal degradation [ 21 27 ] . The later process involves the deacetylation and ubiquitylation of the p53 protein by mdm2 [ 28 ] . Inactivation and/or degradation of p53 diminishes the cell ability to undergo apoptosis [ 21 ] . Conversely, p53 may influence mdm2.
The N9 murine microglia cell line was a gift kindly provided by Dr. P. Ricciardi-Castagnoli [ 62 ] . This cell line has been used extensively as a model for microglia [ 63 64 65 ] . These cells were derived by immortalization of day 13 embryonic brain cultures with a retrovirus carrying an activated v-myc oncogene.
7 % concordance), except for very lowly expressed genes such as the RAS oncogene.
A high prevalence of 3q amplification has been reported in many studies on tobacco-associated cancers, including those of the lung, cervix and esophagus [ 11 13 14 15 16 17 ] . We and others have shown that PIK3CA is a candidate oncogene at 3q in these tumors [ 12 18 19 ] . Interestingly, PI3K pathway has been suggested to play a role in modulating the effects of benzopyrene, a tobacco-derived carcinogen, and its metabolite, anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-terahydrobenzopyrene [ 20 ] .
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