Words similar to oncogene
Example sentences for: oncogene
How can you use “oncogene” in a sentence? Here are some example sentences to help you improve your vocabulary:
RNA for the Incyte platform experiments was poly(A)+ RNA prepared from HEK293 human cells that expressed a mutant (S45Y) β-catenin oncogene [ 11 12 ] . Other samples (e.g.
One of the hallmarks of cancer includes the accumulation of mutations in key genes, namely DNA repair genes [ 4 ] , tumor suppressor genes [ 5 6 ] , and proto-oncogenes [ 5 6 ] , accompanied by the loss of the wildtype allele, resulting in loss of heterozygosity [LOH, see reviews by [ 7 8 9 ] ]. Pancreatic cancer, which results in the death of approximately 30,000 Americans annually and is the fourth leading cause of cancer mortalities in the United States, exhibits this hallmark [ 10 ] . For example, in pancreatic cancer there is a high incidence of mutations (>50%) in the tumor suppressor genes p16, p53 and DPC4 and approximately 90% of cases coincide with a mutation in the oncogene K- ras 2 [see review by [ 11 ] ]. Furthermore, a significant percentage of tumors harboring a mutated copy of DPC4 or p53 also lose the corresponding wildtype allele, resulting in LOH [see reviews by [ 11 12 ] ].
RU 486 also increased the hepatic mRNA levels of the oncogene mdm2 by 21 ± 7% (Fig 2B).
BRCA1 ribonuclease protection probe was made using an in vitro transcription kit (Ambion, Inc, Austin, TX, USA) as previously described [ 10] and derived clones were tested for protein levels by Western blot analysis using an anti-BRCA1 (Oncogene Research, Ab-1, Cambridge, MA, USA) antibody.
To identify putative luteolytic factors that initiate CLENDO cell apoptosis, cells were treated with TNFα (50 ng/ml; Upstate Biotechnology, Inc.; Lake Placid, NY), bovine IFNγ (200 IU/ml; generous gift from Dr. Dale Godson, Veterinary Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada), sFasL (50 ng/ml; Oncogene, LaJolla, CA), mouse Fas activating antibody (Jo2; 500 ng/ml; Pharmingen, San Diego, CA), human Fas activating antibody (CH-11; 500 ng/ml; Upstate Biotechnology, Inc., Lake Placid, NY), PGF
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