Words similar to oncogene
Example sentences for: oncogene
How can you use “oncogene” in a sentence? Here are some example sentences to help you improve your vocabulary:
One of the hallmarks of cancer includes the accumulation of mutations in key genes, namely DNA repair genes [ 4 ] , tumor suppressor genes [ 5 6 ] , and proto-oncogenes [ 5 6 ] , accompanied by the loss of the wildtype allele, resulting in loss of heterozygosity [LOH, see reviews by [ 7 8 9 ] ]. Pancreatic cancer, which results in the death of approximately 30,000 Americans annually and is the fourth leading cause of cancer mortalities in the United States, exhibits this hallmark [ 10 ] . For example, in pancreatic cancer there is a high incidence of mutations (>50%) in the tumor suppressor genes p16, p53 and DPC4 and approximately 90% of cases coincide with a mutation in the oncogene K- ras 2 [see review by [ 11 ] ]. Furthermore, a significant percentage of tumors harboring a mutated copy of DPC4 or p53 also lose the corresponding wildtype allele, resulting in LOH [see reviews by [ 11 12 ] ].
The mechanism of p53 activation in response to either DNA damage or oncogene expression occurs through stabilization of the p53 protein.
Whole cell lysate (50 μg) was loaded onto a 6% sodium dodecyl sulfate-polyacrylamide gel electrophoresis gel, transferred to nitrocellulose, and hybridized with an anti-BRCA1 (Ab-1; Oncogene Research, Cambridge, MA, USA) antibody as previously described [ 10].
Herein we sought to modulate anti-tumor immunity in a transgenic mouse tumor model in which an oncogene, SV40 large T antigen (Tag), is expressed in islet beta cells under the control of the rat insulin promoter, Rip1 [ 23 ] . Several lines of Rip1-Tag mice have been generated and characterized.
Experiments used the chimeras expressed either via the pJ3H vector, or the HA-tagged chimera subcloned into the expression vector pMEXneo [ 48 ] . The oncogene v-crk and its mutants cloned into pMEXneo have been described [ 49 50 ] .
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