Words similar to ocular
Example sentences for: ocular
How can you use “ocular” in a sentence? Here are some example sentences to help you improve your vocabulary:
The ocular phenotypes of Bmp4 mutant mice show that BMP4 is a strong candidate to contribute to Axenfeld-Rieger anomaly and other developmental conditions associated with human glaucoma.
An accumulation of 4-HNE-conjugated protein has been detected in lesions of aging-related diseases, including Parkinson's disease [ 53 ] and Alzheimer's disease [ 54 ] . It also accumulates in the affected neuronal tissues of experimental animals experiencing brain ischemia [ 55 56 ] and traumatic spinal cord injury [ 57 ] . 4-HNE can impair synaptosomal membrane proteins, glutamate transport and importantly, mitochondrial functions [ 58 59 ] . Evidence indicates that 4-HNE increases neuronal susceptibility to oxidative stress [ 60 ] and serves as a mediator of oxidative stress that leads to neuronal apoptosis [ 61 ] . As indicated in the Introduction, 4-HNE has been implicated in some ocular pathological conditions [ 19 20 ] .
Glaucoma is a leading cause of blindness that involves loss of retinal ganglion cells and degeneration of the optic nerve [ 1 ] . Glaucoma is usually associated with high intraocular pressure (IOP) that results from an increased resistance to drainage of the ocular fluid [ 1 ] . Developmental disorders of the ocular anterior segment, including Axenfeld-Rieger syndrome, are often associated with elevated IOP and glaucoma [ 1 2 ] . The developmental sequence and structure of the human and mouse ocular drainage structures are similar [ 3 ] , and the same genes are known to cause anterior segment dysgenesis (ASD) in humans and mice.
This seems a reasonable possibility, although it does not explain why most of the ocular serovars have maintained a TrpEb that seems to have resisted reductive evolutionary forces.
Rabbits have been successfully used as a model of glucocorticoid-induced ocular hypertension [ 23 24 25 26 27 ] . In order to study the association of MYOC gene expression with steroid-induced ocular hypertension, it will be helpful to know the sequence of rabbit myocilin.
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