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Example sentences for: nt-

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We processed four ears of P0 and P8 Brn3c null and control littermates for expression of BDNF and NT-3 using the riboprobes previously described [ 7 ] . We did not analyze neurotrophin expression in 6-month old animals as neurotrophins are downregulated in neonates [ 20 ] and no expression can be found even in normal animals [ 4 ] . In the canal cristae we expected, and found, only a BDNF signal.
The progressive loss of afferent and efferent innervation in Brn3c null mutants shows neither in spatial nor in temporal pattern a resemblance to losses reported in simple BDNF or NT-3 null mutations [ 6 ] . Null mutants of ear specific neurotrophins have completed the loss of sensory neurons before birth.
The NT-3 signal in the area of the cochlea that corresponds to the IHC's persisted at least until P8 in the apex of Brn3c null mice (Fig.
No selective loss of spiral neurons is observed in Brn3c null mutants in the basal turn, a feature of either NT-3 or trkC loss [ 6 9 14 ] . Likewise, the innervation of the apex (Fig.
Past work has shown that BDNF and NT-3 appear to shift in their expression into inner hair cells around birth or are lost in the ear and other parts of the nervous system [ 6 10 20 23 ] . It has been suggested that other neurotrophins may come into play in the ear [ 11 ] . However, the apex of Brn3c null mutants, which retains most of the spiral neuron afferents at 6-month, shows no formation of mature hair cells at any time surveyed here (P0, P8, P10).