Example sentences for: nt-
How can you use “nt-” in a sentence? Here are some example sentences to help you improve your vocabulary:
Moreover, recent work shows that in embryos NT-3 is primarily expressed in supporting cells, moving only around birth into hair cells [ 6 7 ] . In fact, the selective loss of vestibular as compared to cochlear sensory neurons (77% versus 29%; [ 3 ] ) suggests that NT-3 expression may be less downregulated in Brn3c null mutants than BDNF [ 6 8 9 ] , provided that at least some differentiation of supporting cells takes place.
[ 5 ] . BDNF transiently stabilizes silent NM synapses during the period of transition from polyneuronal to mononeuronal innervation of skeletal muscle fibers [ 6 ] . BDNF and CNTF cooperatively affect efficiency of embryonic xenopus neuromuscular synapses in culture [ 7 8 ] . BDNF stimulates transmitter release from neuromuscular synapses [ 9 ] and enhances the efficiency of transmission at the neuromuscular synapse [ 10 ] . BDNF, together with NT-3, can restore neuregulin levels and a normal distribution of AchR at the neuromuscular junction blocked with curare [ 11 ] . BDNF, in conjunction with fibronectin, increases spontaneous synaptic currents in the cultured embryonic xenopus neuromuscular junction [ 12 ] . BDNF down-regulates AchR clustering, most likely by binding to TrkB expressed in myocytes [ 13 ] . BDNF downregulates agrin levels in muscle but increases neuregulin in ventral horn spinal motor neurons at the time when they form neuromuscular synapses [ 14 ] .
Those data are also consistent with the formation of a crude cochleotopic projection in NT-3 null mutants [ 6 14 ] . Those mutants have a much more severely reduced density of innervation in the developing cochlea [ 6 14 ] than the reduction we found in Brn3c null mutants at P0.
The NT-3 signal in the area of the cochlea that corresponds to the IHC's persisted at least until P8 in the apex of Brn3c null mice (Fig.
We processed four ears of P0 and P8 Brn3c null and control littermates for expression of BDNF and NT-3 using the riboprobes previously described [ 7 ] . We did not analyze neurotrophin expression in 6-month old animals as neurotrophins are downregulated in neonates [ 20 ] and no expression can be found even in normal animals [ 4 ] . In the canal cristae we expected, and found, only a BDNF signal.
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