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Example sentences for: nt-

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The comparatively high level of NT-3 expression in Brn3c null mutant cochlea, which has been shown to be the neurotrophin most prominently supporting spiral sensory neurons [ 6 9 14 ] , is in agreement with the normal development of cochlear innervation in newborn Brn3c null mutants.
Four ears each of Brn3c null mutants (P0 and P8) and control littermates were embedded in paraffin, sectioned and probed for the presence of BDNF and NT-3 mRNA using the in situ technique previously described [ 7 ] . Sections were lightly counterstained and viewed with bright and dark field microscopy.
Those data are also consistent with the formation of a crude cochleotopic projection in NT-3 null mutants [ 6 14 ] . Those mutants have a much more severely reduced density of innervation in the developing cochlea [ 6 14 ] than the reduction we found in Brn3c null mutants at P0.
Past work has shown that BDNF and NT-3 appear to shift in their expression into inner hair cells around birth or are lost in the ear and other parts of the nervous system [ 6 10 20 23 ] . It has been suggested that other neurotrophins may come into play in the ear [ 11 ] . However, the apex of Brn3c null mutants, which retains most of the spiral neuron afferents at 6-month, shows no formation of mature hair cells at any time surveyed here (P0, P8, P10).
However, there was a surprisingly strong NT-3 signal over the organ of Corti in the apex of Brn3c null littermates (Fig.