Words similar to nrbmrna

Example sentences for: nrbmrna

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We have previously investigated nmt55/p54 nrbprotein expression in human breast tumors and observed a statistically significant association between decreased nmt55/p54 nrbexpression, loss of hERα and hPR and increased tumor size [ 13 ] . It is possible that decreased nmt55/p54 nrbexpression represents poor tumor differentiation, increased tumor growth and metastases since reduced or absent hERα expression and function correlates with poor tumor differentiation [ 11 36 ] and tumor size is a strong indicator of tumor progression [ 37 ] . Here we investigated nmt55/p54 nrbmRNA expression using Northern blot analyses and ribonuclease protection assays to determine if the reduction of nmt55/p54 nrbprotein expression was the result of transcriptional regulation.
Figure 2shows Northern blot analysis of nmt55/p54 nrbmRNA expression in 12 human breast tumors.
These different nmt55/p54 nrbmRNA levels were not due to differential RNA loading, as GAPDH levels were similar in all tumor samples.
It also suggested that nmt55/p54 nrbprotein expression in some breast tumors does not correlate with nmt55/p54 nrbmRNA expression.
Since there was no apparent nmt55/p54 nrbmRNA regulation in ER+ or ER- human breast tumors, it was possible that monoclonal antibody NMT-1 may not detect the presence of potential multiple isoforms of nmt55/p54 nrbprotein especially in ER- tumors.