Words similar to nrbprotein

Example sentences for: nrbprotein

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Thus, loss of nmt55/p54 nrbprotein or the expression of nmt55/p54 nrbprotein variants in tumor cells may result in the loss of hERα expression, the expression of nonfunctional hERα or the altered expression other critical cell growth factors due to lack of proper pre-mRNA splicing.
The immunohistochemistry data confirm the results obtained by Western blot analyses, suggesting that nmt55/p54 nrbprotein is expressed in various isoforms in a subset of ER+ human breast tumors.
This confirmed the previous observations obtained with monoclonal antibody NMT-1 [ 13 ] . Data also showed that a subset of ER+ tumors expressed nmt55/p54 nrbprotein detectable with polyclonal antibody NMT-5 and monoclonal antibody NMT-1 but not polyclonal antibody NMT-4.
Since there was no apparent nmt55/p54 nrbmRNA regulation in ER+ or ER- human breast tumors, it was possible that monoclonal antibody NMT-1 may not detect the presence of potential multiple isoforms of nmt55/p54 nrbprotein especially in ER- tumors.
A plausible explanation for the lack of nmt55/p54 nrbprotein detection with polyclonal antibody NMT-4 is a point mutation in the epitope for polyclonal antibody NMT-4, a post-translational modification, such as phosphorylation, in or near this epitope or an alternative splice variant affecting this epitope.