Words similar to nrbprotein

Example sentences for: nrbprotein

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Thus, loss of nmt55/p54 nrbprotein or the expression of nmt55/p54 nrbprotein variants in tumor cells may result in the loss of hERα expression, the expression of nonfunctional hERα or the altered expression other critical cell growth factors due to lack of proper pre-mRNA splicing.
These results, together with those reported previously [ 13 ] , further suggest that decreased expression of nmt55/p54 nrbprotein in ER- human breast tumors is likely a post-transcriptional event.
This confirmed the previous observations obtained with monoclonal antibody NMT-1 [ 13 ] . Data also showed that a subset of ER+ tumors expressed nmt55/p54 nrbprotein detectable with polyclonal antibody NMT-5 and monoclonal antibody NMT-1 but not polyclonal antibody NMT-4.
These results indicate that monoclonal antibody NMT-1 (carboxyl terminal) and the polyclonal antibodies NMT-4 (amino terminal) and NMT-5 (mid-region) detect nmt55/p54 nrbprotein with high affinity and high specificity.
A plausible explanation for the lack of nmt55/p54 nrbprotein detection with polyclonal antibody NMT-4 is a point mutation in the epitope for polyclonal antibody NMT-4, a post-translational modification, such as phosphorylation, in or near this epitope or an alternative splice variant affecting this epitope.