Words similar to nrbmay
Example sentences for: nrbmay
How can you use “nrbmay” in a sentence? Here are some example sentences to help you improve your vocabulary:
The absence or reduced expression of nmt55/p54 nrbmay be attributed to the regulation of mRNA expression, protein processing of a specific functional domain or the presence of a heterogeneous population of nmt55/p54 nrbisoforms which may not be immunodetected by monoclonal antibody NMT-1.
It has been proposed that loss of hERα expression in breast tumors is the result of aberrant RNA processing [ 40 41 42 43 ] . These aberrantly spliced mRNAs, if translated, could lead to truncated receptors with hormone binding but not DNA binding function [ 44 ] . Further, there is evidence for the role of RNA processing in oncogenesis [ 45 46 ] . Many studies, including those on human hnRNP A2/B1 and the CD44 gene, suggest that high fidelity pre-mRNA splicing is critical to normal cellular function and may play a key role in oncogenesis and breast cancer progression [ 47 48 ] . The strong association between nmt55/p54 nrband hERα expression indicates that nmt55/p54 nrbmay be an important marker for breast cancer progression.
Our data suggests that nmt55/p54 nrbmay be critical to cell growth and function, such that, decreased nmt55/p54 nrbexpression in ER- human breast tumors or the expression of nmt55/p54 nrbvariants in ER+ tumors may indicate loss of normal growth, nmt55/p54 nrbhas been shown in several studies to bind RNA and interact with PSF and Topoisomerase I [ 14 16 17 18 19 20 39 ] . Those results along with our observations that nmt55/p54 nrbassociates with several splicing factors essential for spliceosome formation (unpublished) and relates to tumor hormonal status [ 13 ] suggest that nmt55/p54 nrbmay be involved in pre-mRNA processing.
To test the possibility that nmt55/p54 nrbmay be transcriptionally downregulated in ER- tumors, we analyzed mRNA levels from a series of human breast tumors utilizing Northern blot analyses and ribonuclease protection assays.
The decreased or altered expression of nmt55/p54 nrbmay be related to tumor differentiation, unregulated tumor cell growth and metastases and may explain tumor heterogeneity, especially with respect to hormonal interventions in the course of treatment.
Loading...