Words similar to non-synonymous

Example sentences for: non-synonymous

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For each orthologous gene set, pairwise estimates of the synonymous (K s ) and non-synonymous (K a ) substitution rates were obtained from nucleotide-coding sequence alignments using the Pamilo-Bianchi-Li method [ 34, 35] implemented in the PBLtest program (I.B.R.
Early tools using phylogenetic and structural information have shown promise in predicting the functional consequences of a mutation [ 13 ] . These reports predict that anywhere between 20-36% of non-synonymous SNPs alter the function of a gene's protein product.
From this analysis, we estimated the rates of total synonymous and non-synonymous substitutions for 200 fragments that were aligned in-frame and then analyzed with the program NAGV2 [ 26 ] using the methods of Nei and Gojobori [ 27 ] . The results of these analyses show that the average nucleotide diversity between the two species is 2.59% ± 0.06% (range 0% to 18.
Abcg8 . However, only one non-synonymous nucleotide change, G1754T, resulting in a conservative cysteine substitution for glycine at amino acid 583 (Gly583Cys) in sterolin-1 was identified (Fig.
Synonymous and non-synonymous substitution rates were calculated by the Synonymous/non-synonymous Analysis Program (SNAP) provided by Los Alamos National Laboratory http://hiv-web.lanl.gov/using the codon-based NA alignment of the high homology group.