Words similar to non-synonymous

Example sentences for: non-synonymous

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Likewise, the oriC region in M. paratuberculosis was found to share a high level of nucleotide identity (~98%) with M. avium . Calculation of the rates of total nucleotide diversity (3) and synonymous substitution per synonymous site (ds) and non-synonymous substitution per non-synonymous site (dn) revealed patterns of variation within the range observed from sequence data outside the oriC region.
In conclusion, there are estimated to be 30,000 non-synonymous differences between an individual and the draft genome [ 23 5 7 8 9 ] . Determination of which positions are likely to be disease associated is a challenging and important problem.
A number of cases of positive selection at the molecular level have been supported by comparison of the rates of synonymous (K s ) and non-synonymous (K a ) substitution [ 3].
Early tools using phylogenetic and structural information have shown promise in predicting the functional consequences of a mutation [ 13 ] . These reports predict that anywhere between 20-36% of non-synonymous SNPs alter the function of a gene's protein product.
These calculations showed a high degree of similarity between the two sequences and a predominance of synonymous over non-synonymous substitutions (Fig.