Words similar to non-transgenic
Example sentences for: non-transgenic
How can you use “non-transgenic” in a sentence? Here are some example sentences to help you improve your vocabulary:
No nuclear staining was seen in these structures in most non-transgenic animals, suggesting that weak activation of Wnt signaling may occur with overexpression of wild type β-catenin protein.
As has been previously reported, in non-transgenic animals we detected nuclear β-catenin only in the thalamus and other deep grey matter structures [ 31 ] . In transgenic lines expressing mutant, stabilized protein, immunohistochemical analysis revealed nuclear β-catenin in both internal granule layer (IGL) and molecular layer neurons of the cerebellum.
In order to determine if cyclin D 1 plays a role in this hyperplasia, kidneys from three proteinuric 40-day old transgenic siblings and three non-transgenic littermates were stained by immunohistochemistry with antibody to phospho-pRb (Ser780), a site of cyclin D 1 /CDK-4/6 phosphorylation not targeted by cyclin E/CDK-2 complexes that disrupts pRb/E2F binding for G 1 → S progression [ 24 ] . Figure 1depicts the intense, heterogeneous nuclear staining of glomerular podocytes and tubular epithelium from hyperplastic nephrons in the diseased transgenics versus the absent staining of nephrons in the non-transgenics consistent with the very low mitotic index in normal kidneys of adult animals [ 26 ] . This suggests that cyclin D 1 is promoting cell-cycle progression during the proliferation of epithelium in diseased kidneys.
Nuclear β-catenin was detected in the thalami and other cortical deep grey matter loci in both transgenic and non-transgenic animals.
While a number of transgenic animals died in the first nine months, the percentage of animals surviving was not significantly different between the transgenic and non-transgenic groups (Table 1).
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