Words similar to nfkb
Example sentences for: nfkb
How can you use “nfkb” in a sentence? Here are some example sentences to help you improve your vocabulary:
As is the case for several other genes found in this study, the TNFR-1/NFkB pathway is associated with p53/p21 WAF-1tumor suppressor systems [ 33 34 35 36 37 ] .
report a close relationship between IL-8 secretion in cystic fibrosis cells and expression of genes from the TNFR-1/NFkB pathway.
In the hippocampus, dietary LC-PUFA activated a different set of transcription factors than observed in the liver, including: nuclear factor of κ light chain gene enhancer in B cells 1 p105 (Nfkb1); nescient helix loop helix 1 (Nhlh1); E2F transcription factor 3 (E2f3); basic transcription factor 3 (Btf3); inhibitor of DNA binding 1 (Idb1); D site albumin promoter binding protein (Dbp); paired box gene 9 (Pax9); and the ELK1 member of the ETS oncogene family.
The first, the ER overload response, triggers the activation of the transcription factor NFkB and the subsequent upregulation of inflammatory proteins [ 13 ] . The second, the unfolded protein response (UPR) induces three divergent cellular events: (i) the activation of transcription factor ATF6 leading to the upregulation of ER chaperones such as protein disulfide isomerase, (ii) upregulation of the pro-apoptotic transcription factor GADD153 and (iii) suppression of protein synthesis via phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by pancreatic eIF2α kinase (PEK/PERK, [ 11 12 ] ). Upregulation of the ER chaperones, GADD153 and PERK in response to a toxic insult would constitute direct evidence of an ER stress response.
Ongoing studies will attempt to elucidate the mechanism of action behind the phenomenon such as the effects on downstream signaling pathways including NFkB, and apoptosis.
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