Words similar to myocyte
Example sentences for: myocyte
How can you use “myocyte” in a sentence? Here are some example sentences to help you improve your vocabulary:
This observation represents animportant finding in demonstrating the effectiveness of a cardiovasculardrug to protect against continual cardiac myocyte apoptosis in failinghearts in vivo . Furthermore, the inhibition of apoptosisby carvedilol was accompanied by signs of improvement in left ventricularfunction and heart size (i.e.
Recent studies have proposed that myocyte loss incardiomyopathy can occur by apoptosis without an inflammatory response [reviewedin [ 1 2 3 ] ]. In heart failure,growth stimulation initially occurs as a compensatory effort tomeet chronically altered hemodynamic demands and is mediated by systemicand/or local up-regulation of mediators of adrenergic pathways andby various cytokines [ 4 5 ] . However, cytokinescan be directly toxic to cardiac myocytes and result in increasedapoptotic cell death [ 3 6 ] . Local up-regulationof angiotensin II induces immediate-early genes, which may leadto increased protein synthesis and myocardial hypertrophy or, alternatively,may up-regulate expression of apoptotic proteins (such as p53) incardiac myocytes.
The initial increase in circulating norepinephrineis thought to maintain cardiac function through inotropic mechanisms.However, a direct cardiac myocyte toxicity from norepinephrine iswell recognized [ 6 7 ] . Furthermore, pressure-overloadand stretch associated release of angiotensin II has been shownto induce myocyte apoptosis [ 8 9 10 ] .In an elegant paper by Telger et al.
These observations,and the results from several animal models, demonstrate that apoptoticcells are present in failing hearts, suggesting that apoptosis mightbe a mechanism involved, at least in part, in the progression ofheart failure and the reduction of myocyte mass.
The development of well-characterized cardiac progenitor cells offers the promise of using real genetic-based approaches to rapidly define the complex pathways that guide cardiac contractility, excitability, and lineage diversification into atrial, ventricular, and conduction system myocyte cell lineages.
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