Example sentences for: myocyte

How can you use “myocyte” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The furazolidone-induced turkey model is a well characterizedexperimental model of dilated cardiomyopathy with features verysimilar to those found in human heart failure [ 19 20 21 22 ] .Decreased contractile function (reduced fractional shortening ofthe left ventricle) and morphological changes (increased heart volumes,left ventricular dilatation, and myocyte hypertrophy) are characteristic featuresof this model [ 21 22 ] .

  • These observations,and the results from several animal models, demonstrate that apoptoticcells are present in failing hearts, suggesting that apoptosis mightbe a mechanism involved, at least in part, in the progression ofheart failure and the reduction of myocyte mass.

  • The initial increase in circulating norepinephrineis thought to maintain cardiac function through inotropic mechanisms.However, a direct cardiac myocyte toxicity from norepinephrine iswell recognized [ 6 7 ] . Furthermore, pressure-overloadand stretch associated release of angiotensin II has been shownto induce myocyte apoptosis [ 8 9 10 ] .In an elegant paper by Telger et al.

  • Recent studies have proposed that myocyte loss incardiomyopathy can occur by apoptosis without an inflammatory response [reviewedin [ 1 2 3 ] ]. In heart failure,growth stimulation initially occurs as a compensatory effort tomeet chronically altered hemodynamic demands and is mediated by systemicand/or local up-regulation of mediators of adrenergic pathways andby various cytokines [ 4 5 ] . However, cytokinescan be directly toxic to cardiac myocytes and result in increasedapoptotic cell death [ 3 6 ] . Local up-regulationof angiotensin II induces immediate-early genes, which may leadto increased protein synthesis and myocardial hypertrophy or, alternatively,may up-regulate expression of apoptotic proteins (such as p53) incardiac myocytes.

  • The development of well-characterized cardiac progenitor cells offers the promise of using real genetic-based approaches to rapidly define the complex pathways that guide cardiac contractility, excitability, and lineage diversification into atrial, ventricular, and conduction system myocyte cell lineages.


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