Words similar to myocyte
Example sentences for: myocyte
How can you use “myocyte” in a sentence? Here are some example sentences to help you improve your vocabulary:
This is consistent with previous observations that M6P/IGF2R knockout mice displayed generalized increased growth and cardiomygaly (resulting from cardiac myocyte hyperplasia) [ 34 ] , and that antisense-mediated reduction of M6P/IGF2R expression enhances tumorigenicity in JEG-3 cells [ 43 ] . Thus, loss or mutation of M6P/IGF2R may contribute to development and progression of tumors via different pathways: by increasing the mitogenic activity of IGF-II and decreasing the apoptotic signaling of TGF-β and lysosomal proteases.
have demonstrated that spontaneously hypertensive rats(SHR) with symptoms of heart failure had significantly higher levels ofapoptotic myocytes than control myocytes [ 37 ] .When treated with an angiotensin-converting enzyme inhibitor, thenumber of apoptotic cells in the SHR with symptoms of heart failurewas dramatically reduced to control levels; controls were SHR withoutsymptoms of heart failure [ 37 ] . Kajstura et al.have also reported that angiotensin II increased the percentageof apoptotic cells in isolated adult rat ventricular myocytes, andthis effect was mediated by AT-1 receptors [ 38 ] .Although ventricular function was not assessed in these studies,the observations raise the possibility that, like our findings withcarvedilol, the beneficial effect of ACE-inhibitors or AT-1 receptorblockers in heart failure may in part be attributed to an inhibitionof myocyte apoptosis with a resultant improvement in in vivo cardiacfunction, a concept that needs further study.
With the clear demonstration that cardiac myocyte apoptosis ispresent in our heart failure model strategies for prevention ofapoptosis can be tested.
This observation represents animportant finding in demonstrating the effectiveness of a cardiovasculardrug to protect against continual cardiac myocyte apoptosis in failinghearts in vivo . Furthermore, the inhibition of apoptosisby carvedilol was accompanied by signs of improvement in left ventricularfunction and heart size (i.e.
One of the difficulties with alchemy and this new age of cardiac myocyte biology is related to defining a rigorous set of criteria that allow one to make the claim that the cell type of interest is truly a cardiac progenitor or stem cell and is acquiring a fully differentiated phenotype [4].
Loading...