Example sentences for: myofibroblasts

How can you use “myofibroblasts” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • When grown in vitro keloid fibroblast cultures contain a high percentage of α-smooth muscle actin (α-SMA) expressing cells - myofibroblasts.

  • Cellular FN is abundantly present in granulation tissue, is produced primarily by the wound fibroblasts and myofibroblasts.

  • Progression of granulation tissue to neodermis requires a decrease in cellularity through apoptosis of endothelial cells, fibroblasts and myofibroblasts [ 28 29 ] . Keloid fibroblasts demonstrate aberrant apoptotic behavior [ 30 31 ] although studies have given variable results [ 5 9 11 30 31 32 33 34 35 ] . Our initial data for serum-starvation-induced apoptosis in monolayer cultures of dermal fibroblasts demonstrated delayed apoptosis of keloid fibroblasts and a negative correlation with α-SMA expression [ 36 ] . Similar correlations were observed in rat lung fibroblasts, where TGFβ1 increased α-SMA content while acting as an antiapoptotic agent [ 37 38 ] . It should be noted however, that many of the myofibroblasts were still able to undergo apoptosis consistent with in vivo data on palatal wound healing [ 39 ] . Thus, TGFβ1 can promote both α-SMA expression in the initial stages of wound healing and apoptosis in later stages of wound healing.

  • However, during granulation tissue remodeling in vivo, decreased cellularity may be the result of apoptosis of fibroblasts and myofibroblasts [ 29 ] .

  • The decrease in percentage of myofibroblasts in the relaxed gels containing keloid fibroblasts (compare Fig.


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