Words similar to myoc

Example sentences for: myoc

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The nucleotide sequence for rabbit MYOC reported in this manuscript has been submitted to GenBank (AY191317).
Analysis of Myoc
Mutations in MYOC have been shown to be causative for primary open angle glaucoma (POAG) [ 1 2 3 ] . Glucocorticoids have been implicated in ocular hypertension and glaucoma due to increased plasma cortisol levels [ 4 5 ] and altered cortisol metabolism [ 6 7 ] in POAG patients and from the increased risk of developing POAG in steroid-responsive patients [ 8 9 ] . Myocilin has been shown to be upregulated in glucocorticoid-treated human trabecular meshwork (TM) cells [ 10 11 ] , and there is variable evidence for increased MYOC expression in glaucomatous individuals [ 12 13 14 ] . In addition, glaucoma patients have a higher chance of responding to steroids than non-glaucomatous individuals.
Transfected plasmid DNA included wild-type human MYOC (pcDNA3.hMYOC; [ 12 ] ), wild-type rabbit MYOC (pcDNA3.RbMYOC.ex1-3), N-terminal 14 amino acid deleted human MYOC (pcDNA3.hMYOC.ΔN14), N-terminal 32 amino acid deleted human MYOC (pcDNA3.hMYOC.ΔN32), or N57S human MYOC (pcDNA3.hMYOC.N57S).
Rabbits have been successfully used as a model of glucocorticoid-induced ocular hypertension [ 23 24 25 26 27 ] . In order to study the association of MYOC gene expression with steroid-induced ocular hypertension, it will be helpful to know the sequence of rabbit myocilin.