Words similar to myocytes
Example sentences for: myocytes
How can you use “myocytes” in a sentence? Here are some example sentences to help you improve your vocabulary:
First, PMA reduces the sensitivity of K ATP to ATP as reports using myocytes [ 17 18 19 20 ] . Second, PMA may reduce ATP production.
These transcription factors are known to be important for the expression of genes in myocytes.
Recently, it has been noted that the JNK and p38 pathways can be activated by G-protein coupled receptor agonists, notably angiotensin II, in vascular smooth muscle cells [ 19 20 ] . In cardiac myocytes, both the p38 and JNK pathways have been activated by endothelin-1 (ET-1) and the α 1 adrenergic receptor agonist phenylephrine [ 21 ] . The ability of the JNK and p38 pathways to be activated by the same agonists of G-protein coupled receptors which activate the ERK pathway led to the investigation of 5-HT as a possible activator of the JNK and p38 pathways.
In cardiac myocytes, PMA is known to activate K ATP through activation of PKC [ 18 19 20 ] . In insulin-secreting cell lines as well, PKC activation by PMA was shown to potentiate K ATP activity [ 11 12 ] . In the present study, however, the activation of K ATP activity by PMA is independent on activation of PKC for two reasons.
have demonstrated that spontaneously hypertensive rats(SHR) with symptoms of heart failure had significantly higher levels ofapoptotic myocytes than control myocytes [ 37 ] .When treated with an angiotensin-converting enzyme inhibitor, thenumber of apoptotic cells in the SHR with symptoms of heart failurewas dramatically reduced to control levels; controls were SHR withoutsymptoms of heart failure [ 37 ] . Kajstura et al.have also reported that angiotensin II increased the percentageof apoptotic cells in isolated adult rat ventricular myocytes, andthis effect was mediated by AT-1 receptors [ 38 ] .Although ventricular function was not assessed in these studies,the observations raise the possibility that, like our findings withcarvedilol, the beneficial effect of ACE-inhibitors or AT-1 receptorblockers in heart failure may in part be attributed to an inhibitionof myocyte apoptosis with a resultant improvement in in vivo cardiacfunction, a concept that needs further study.
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