Words similar to monomers
Example sentences for: monomers
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The p51 subunit is generated via endoproteolytic cleavage of the p66 subunit between Phe 440 and Tyr 441 [ 5 6 ] . The larger subunit (p66) contains both polymerase and RNase H activities, while the smaller subunit (p51) lacks these functions, in context of the heterodimer [ 7 8 ] . However, both the p66 and p51 monomers are functionally inactive when dissociated from each other [ 9 ] . Several years have passed since it was first suggested that agents that could specifically disrupt the dimerization of HIV-1 RT might prove a worthwhile antiretroviral strategy [ 10 ] , though such agents have yet to be developed.
The crystal structure of two consecutive AChBP monomers [ 6 ] was used as a template to build a homology-model of four known native human nAChR subunit interfaces: alpha4-beta2 (I1), alpha4-beta4 (I2), alpha3-beta2 (I3), and alpha7-alpha7 (I4).
For instance, DnaA monomers bind to specific, non-palindromic 9-nucleotide sequences called DnaA boxes, and this interaction is thought to initiate replication.
From this, an average density of myosin-II per μm 3was determined to be approximately 2000 monomers per μm 3(approximately 3.4 μM) so that the amount of myosin-II in any cell with a particular volume could be estimated, assuming that the average concentration remains the same.
The assembly of myosin II monomers into filaments is regulated by phosphorylation of its heavy chains at three threonine residues at the C-terminus of the tail [ 9 10 ] . Dephosphorylation of these threonines is a prerequisite of filament assembly, as confirmed by the phenotypes of a 3xAsp mutant, in which the three threonines are replaced by three aspartate residues (mimicking the phosphorylated state) [ 11 ] . In vitro the 3xAsp myosin II is severely impaired for filament assembly, and in vivo 3xAsp myosin II fails to assemble or localize to the cortical cytoskeleton.
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