Words similar to mononuclear
Example sentences for: mononuclear
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Subjects in the initial investigation were participants in an open-label, multicenter, international Phase III study in which patients were randomized to be treated with either the standard-of-care 5-FU/LV chemotherapy (control arm) regimen alone or 5-FU/LV chemotherapy co-administered with SU5416 (treatment arm) administered twice weekly via intravenous infusion at a dose of 145 mg/m 2(for more detail see [ 13 14 ] ). Affymetrix expression profiling technology was applied to RNA from matched peripheral blood mononuclear cell (PBMC) sample pairs (before and after treatment) harvested from subjects, for assessment of changes in gene expression that might correlate with SU5416 administration.
The ability of Mycobacterium tuberculosis bacteria to infect and replicate inside host mononuclear phagocytes is key to its ability to establish an infection and cause tuberculosis.
Contrary to the in vivo observation, however, in vitro stimulation with IL-2 (6,000 IU/ml) of PBMC obtained from apheresis of melanoma patients did not alter mononuclear cell counts, suggesting that cell death is not a direct effect of IL-2 (Figure 1b).
A similar role has been suggested for these transcription factors in the response of intraparenchymal mononuclear cells to hemorrhage [ 50 ] . The fact that NF-κB and CREB activation occurs prior to expression of PI3K and PKB-α indicates that these transcription factors may regulate these proteins in lung neutrophils.
We compared the time course of gene induction after in vitro exposure of peripheral blood mononuclear cells (PBMC) to IL-2 (6,000 IU/ml) with in vivo exposure to a dose regimen (720,000 IU/kg every 8 hours), which is associated with fairly high systemic toxicity and clinical effectiveness [ 16].
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