Words similar to moeb
Example sentences for: moeb
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Two moeB sequences with evidence for function include a knockout of the open reading frame encoding GenBank accession number BAA35521, which was shown to cause the accumulation of precursor Z in E. coli [ 13 ] and accession number Z95150, which was found to be located within a cluster of other MPT-Mo synthesis genes of Mycobacterium tuberculosis [ 14 ] . MSAEs from eukaryotic organisms have also been characterized: MOCS3 (GenBank accession number NM_014484) from humans and cnx 5 from Arabidopsis thaliana [ 15 ] , respectively, have been sequenced, and cnxF from Aspergillus nidulans [ 16 ] has been both sequenced and physiologically characterized.
The crystal structure of the E. coli MoeB-MoaD complex clearly shows the interaction between these two proteins and unambiguously confirms the adenylation role of MoeB [ 7 ] . After a thiocarboxylate moiety is formed on the terminal glycine of each MoaD subunit, the two sulfur atoms are transferred to precursor Z as sulfhydryl groups in a dithiolene configuration.
In terms of distribution, the MoeB structure (146 sequences) was much more common than the MoeBR structure (12 sequences), while MoeZ was represented by only six sequences in the GenBank non-redundant (nr) database.
MoeBR has the ThiF and 2X CXXC domains configured like MoeB but includes an N-terminal rhodanese-like domain, the polyproline motif, and has a Y substitution at position 155 (Ec-MoeB numbering).
The presence of a rhodanese domain in MoeBR and MoeZ suggests that these members of the family may perform an additional function compared to MoeB.
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