Words similar to mhcii
Example sentences for: mhcii
How can you use “mhcii” in a sentence? Here are some example sentences to help you improve your vocabulary:
major histocompatibility complex class II antigens MHCII
[ 36 ] ). It has been shown that treatment of cells with phorbol esters leads to accumulation of phosphorylated H3 histones [ 37 ] . Therefore, it seems possible that in LS1034 cells PMA could enhance transcriptional activity of chromatin at promoters of MHCII and/or CIITA genes.
Although MHCII are not expressed by the vast majority of studied mouse and human tumors, CD4+ T lymphocytes specific to MHCII-restricted tumor antigens have been found in various cancers [ 1 ] . Those lymphocytes are believed to be generated in vivo following the recognition of MHCII-tumor peptide complexes expressed by host antigen presenting cells and can cause regression of MHCII-negative tumors indirectly, via secretion of cytokines such as IL-2 or IFNg [ 2 ] . The released cytokines can recruit and activate cytotoxic CD8+ T lymphocytes and/or accessory cells (eosinophills, macrophages) which further mediate tumor destruction.
In certain types of tissues, ethanol has been shown to induce membrane translocation of PKC isoforms through activation of phospholipase A and release of diacylglycerol [ 40 ] . This mechanism, however, does not appear to be significant in our case as ethanol without PMA failed to potentiate IFNg-induced MHCII expression in LS1034 cells.
Data, plotted in Figure 7, demonstrate that 10 ng/ml Bryostatin added into the culture medium containing 10 2-10 3IU/ml IFNg induced a 5- to 6-fold increase in levels of MHCII expression.
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