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Example sentences for: mhcii

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Thus, histone deacetylase inhibitors - Butyrate and Trichostatin A - can rescue MHCII-inducibility in bladder carcinoma cells [ 14 ] and restore constitutive MHCII expression in plasmacytoma cells [ 35 ] . In addition to acetylation, transcriptional activity of chromatin is also regulated through phosphorylation (reviewed in Ref.
[ 36 ] ). It has been shown that treatment of cells with phorbol esters leads to accumulation of phosphorylated H3 histones [ 37 ] . Therefore, it seems possible that in LS1034 cells PMA could enhance transcriptional activity of chromatin at promoters of MHCII and/or CIITA genes.
While the manuscript was under review, results of a clinical trial had been published showing that a systemic combination treatment with IFNg and GM-CSF for as long as 9-weeks failed to induce MHCII on tumor cells in 9 out of 15 hepatocellular carcinoma patients.
Bryostatin 1 may be considered for further investigation of IFNg-dependent MHCII induction in resistant tumors in vivo .
Figure 2also demonstrates that ethanol was totally inactive alone (compare group 20a vs. 20b) but it significantly improved the MHCII induction in the presence of PMA.