Words similar to mhcii
Example sentences for: mhcii
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While the manuscript was under review, results of a clinical trial had been published showing that a systemic combination treatment with IFNg and GM-CSF for as long as 9-weeks failed to induce MHCII on tumor cells in 9 out of 15 hepatocellular carcinoma patients.
Most frequently, poor MHCII inducibility in response to IFNg has been attributed to alterations in the IFNg signalling pathway and epigenetic silencing of gene expression (reviewed in Ref [ 13 ] ). The cascade of IFNg signalling events leading to transcription activation of MHCII genes has been characterized in great detail (reviewed in Ref [ 30 ] ). Binding of IFNg to its receptor results in JAK-mediated phosphorylation of STAT1 on Tyrosine 701.
Results demonstrate that the expression level of MHCII reached a plateau at 10 3IU/ml IFNg in the presence of 10 2-10 4ng/ml PMA and 172 mM ethanol.
It is well established that, besides the MHCII molecules, IFNg can induce susceptible tumors to upregulate the expression of MHC class I antigens [ 43 ] , tumor associated antigens [ 44 ] , costimulatory molecules [ 45 ] , and heat shock proteins [ 46 ] . In addition, IFNg may have antimetabolic and antiproliferative influence on certain types of tumor cells [ 47 ] . It has also been suggested that IFNg may cause responding tumor cells to secrete angiogenesis inhibitors [ 48 ] . As it is not known which of those IFNg effects are missing or restored by PMA in LS1034 cells, a thorough evaluation of the possible clinical implications of our in vitro findings is quite difficult.
In this study we showed that IFNg-inducibility of MHCII antigens in weakly inducible LS1034 colorectal carcinoma cell line can be rescued by concomitant incubation with PKC agonists.
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