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Example sentences for: mhcii
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This may suggest that either the two PKC activators act through different isoforms of PKC or PMA also activates enzymes outside the PKC family such as MAPK [ 18 ] . Whatever the mechanism, it appears possible to restore the IFNg-dependent MHCII expression in LS1034 cell line by clinically acceptable concentrations of Bryostatin 1.
We also show that the IFNg-dependent MHCII expression in LS1034 cell line can be rescued by clinically acceptable concentrations of Bryostatin 1.
It has been recently appreciated that sufficient concentrations of secreted IFNg may also induce susceptible tumors to express the MHCII molecules, potentially leading to increased direct contact with CD4+ T cells [ 3 ] . Even though some reports indicate that tumor sensitivity to IFNg is not required to elicit tumor regression [ 4 ] , it is conceivable that the IFNg-induced MHCII expression on tumor cells may boost the effector phase of antitumor responses through additional cytokine release or direct tumor eradication by CD4+ T cells.
Data, plotted in Figure 7, demonstrate that 10 ng/ml Bryostatin added into the culture medium containing 10 2-10 3IU/ml IFNg induced a 5- to 6-fold increase in levels of MHCII expression.
Unfortunately, the induction of MHCII on tumor cells by IFNg in vivo is difficult [ 10 ] . In fact, the reported inducible tumors seem to be limited to freshly transplanted tumor cells [ 9 11 ] or malignant cells present in the ascitic fluid [ 12 ] . Many tumors do not express MHCII after treatment with recombinant IFNg in vitro either [ 13 ] .
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