Words similar to mhcii
Example sentences for: mhcii
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MHCII antigens were initially undetectable in all cell lines tested.
Although MHCII are not expressed by the vast majority of studied mouse and human tumors, CD4+ T lymphocytes specific to MHCII-restricted tumor antigens have been found in various cancers [ 1 ] . Those lymphocytes are believed to be generated in vivo following the recognition of MHCII-tumor peptide complexes expressed by host antigen presenting cells and can cause regression of MHCII-negative tumors indirectly, via secretion of cytokines such as IL-2 or IFNg [ 2 ] . The released cytokines can recruit and activate cytotoxic CD8+ T lymphocytes and/or accessory cells (eosinophills, macrophages) which further mediate tumor destruction.
Results demonstrate that the expression level of MHCII reached a plateau at 10 3IU/ml IFNg in the presence of 10 2-10 4ng/ml PMA and 172 mM ethanol.
It remains to be determined whether the restoration of IFNg-induced MHCII expression by PMA is unique to LS1034 cells.
The effect of PKC activators PMA and Bryostatin 1 on IFNg inducibility of MHCII in three resistant tumor cell lines of different histological origin has been examined.