Words similar to metastatic
Example sentences for: metastatic
How can you use “metastatic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Our finding that TYRP-1 is also expressed in the poorly metastatic or noninvasive cell lines NM-2C5 [ 2 ] , T47D, MCF7 and DU145 [ 5 ] , which are derived from human breast cancers and prostate tumors that are nonmetastatic, indicates that this molecule is not exclusively expressed in cells of the melanocytic lineage.
(6) Dehanasekaran et al . [ 11 ] did a study of 60 prostate biopsy samples, 24 non-tumorous,14 tumor in situ, 20 metastatic tumor.
Epigenetic gene silencing of the MGMT confers enhanced sensitivity to alkylating agents in cancer [ 24 25 ] . Lack of methylation, on the other hand, associates with high-risk of death [ 25 26 ] . It has been suggested that the high-levels of MGMT proteins contribute to a drug-resistant phenotype [ 27 ] . More than 90% of newly diagnosed GCTs and 70-80% of patients who present metastatic disease are cured with cisplatin-based chemotherapy [ 28 ] . However, 20-30% of the patients with metastatic disease exhibit resistance to the cisplatin curative regimen leading to high mortality in this group.
This indicates that the increase in markers is related to metastatic invasion of bone and is reflected in systemic marker levels regardless of the potential antiresorptive effects of antineoplastic therapy.
Bone is the most common target site of metastatic invasion in breast cancer [ 1 ] . This is of clinical importance as metastatic bone disease is associated with increased morbidity and excess mortality [ 2 ] . To initiate successful preventive therapy it is thus imperative that the bone metastases are detected early [ 3 ] .
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