Example sentences for: metastasize

How can you use “metastasize” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This suggests that even small and seemingly resectable lung cancers metastasize early.

  • There would also be considerable benefit to the 87% of women with mammary carcinomas who are not likely to metastasize by sparing them the physical, mental and financial costs of the treatment.

  • Breast cancer cells frequently metastasize to bone causing bone destruction and hypercalcemia [ 9 ] . Parathyroid hormone-related protein (PTHrP), secreted by these cells, is a major mediator of the osteolytic process [ 10 ] . Osteolysis leads to the release of TGFβ which, in turn, further induces PTHrP expression [ 11 ] . Other tumor-relevant genes, such as pai-1 or upa , can also be activated by TGFβ.

  • What holds cells together or connects them with the extracellular matrix—and what happens when these interactions break down—is one of the keys to determining how tumors metastasize.

  • Since Pten mutations are usually found in advanced tumors, and the protein has been suggested to inhibit cell spreading, migration, and invasion [ 36, 37], it is possible that the tumors from Wnt-1 TG, Pten +/- mice may have a higher potential to metastasize than those from mice carrying a Wnt-1 transgene in a wild type Pten background.


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