Words similar to metallothionein
Example sentences for: metallothionein
How can you use “metallothionein” in a sentence? Here are some example sentences to help you improve your vocabulary:
Injured adult DRG neurons do not die after axonal injury [ 15 ] as a result of the upregulation of cell survival factors such as the small heat shock protein HSP27 [ 16 ] . We now find several genes that could have a survival-promoting role, including the peripheral benzodiazepine receptor, whose agonists are potent antiapoptotic compounds [ 17 ] , GADD45A, which maintains genomic stability and appears to be anti-apoptotic in neurons after ischemic damage [ 18 ] , metallothionein 1L, which is a free radical scavenger [ 19 ] , GTP cyclohydrolase 1, which is obligatory for the actions of NGF on PC12 cells [ 20 ] , and IES-JE (MCP-1) which attracts macrophages, which in turn have been reported to have a role in neuronal survival [ 21 ] .
Examples include genes for the yeast hexose transporter, whose amplification has been shown to increase fitness in a low-glucose environment [ 49], the nematode P-glycoprotein gene, the classical eukaryotic multidrug-resistance gene [ 36], and the fruit fly copper-binding metallothionein gene whose duplication is implicated in copper tolerance [ 40, 41].
This protective mechanism declines with age because a study analyzing metallothionein levels in RPE of macular region showed a dramatic decrease in aged donors (mean age = 80-yr) as compared to those from younger donors (mean age = 58-yr) [ 36 ] . A separate report concluded that there was also an age-dependent decrease of catalase activity in RPE [ 37 ] . These studies suggest RPE in the elderly are more susceptible to oxidative stress induced damage, which may contribute to age-related RPE dysfunction and vision loss.
An increase of oxidative stress in RPE is associated with an increase of cellular catalase, metallothionein [ 3 ] and glutathione S-transferase [ 35 ] , which should serve as a protective mechanism to decrease the cytotoxicity caused by H 2 O 2 and other reactive oxygen species.
At the time of writing, there were a small number of genes (14) that did not appear to be expressed in the testis of either this BCA model or a second, metallothionein knockout (129SvPCJ background [ 19]), model which was also investigated.
Loading...