Example sentences for: metalloproteinase

How can you use “metalloproteinase” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • AP-1 = activator protein-1; COL2A1 = procollagen 2 alpha 1; egr-1 = early growth response gene-1; ets = erythroblastosis gene twenty-six; IL-1β = interleukin-1β; LH = lactalbumin hydrolysate; LIF = leukemia inhibitory factor; MAPK= mitogen-activated protein kinase; MMP = matrix metalloproteinase; NF-κB = nuclear factor-κB; OA = osteoarthritis; PDGF = platelet-derived growth factor; RT-PCR = reverse transcriptase polymerase chain reaction; SMAD4 = mothers against dpp homolog 4; TGF-β = transforming growth factor-β.

  • APP can also be cleaved by the nonamyloidogenic α-secretases, a disintegrin and metalloproteinase 10 (ADAM-10) and ADAM-17 [3], in a reaction that is believed to occur primarily on the plasma membrane [4] and is known as “ectodomain shedding.”

  • MMP-2 differs from several other members of the metalloproteinase family in that its transcription is not induced in response to the proinflammatory cytokines tumor necrosis factor-α and interleukin-1, and seems primarily regulated post-translationally.

  • In cancer the gelatinases [matrix metalloproteinase (MMP)-2 and MMP-9] have been shown to be associated with tissue invasion and metastatic disease.

  • Despite the uncertainty about the proximal mediator of IDO's effect, it is known that alterations in cell adhesion and metalloproteinase activity are often associated with changes in prostaglandin synthesis [ 27, 28, 29, 30].


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