Words similar to metalloproteinases
Example sentences for: metalloproteinases
How can you use “metalloproteinases” in a sentence? Here are some example sentences to help you improve your vocabulary:
The two major groups of proteinases involved in extracellular matrix degradation - serine proteinases and metalloproteinases - have been grouped by literature profiling (Figure 6b: urokinase plasminogen activation cascade (UPA, PLAUR, SERPIN) and matrix metalloproteinases (MMP14, MMP10, MMP1)).
Matrix metalloproteinases (MMPs) are responsible for modification of the extracellular matrix and are involved in wound healing, tumorigenesis, pregnancy and inflammation.
Several metalloproteinases that are capable of the proteolytic degradation of extracellular matrix are thought to play a major role in the dissolution of the bone and cartilage matrix, allowing the invasive cells to migrate into the stroma across cell boundaries.
The ability of cancer cells to proliferate within a tissue depends on their response to adhesive and growth factor cues within the ECM [ 10 ] , and self-sufficiency in growth signals is one of the hallmarks of cancer [ 11 ] . To stimulate their own growth and proliferation in tissue, tumor cells can overproduce and release their own growth factors or obtain them from the matrix as they are released by matrix metalloproteinases [ 12 ] . The endothelial vasculature grows into the tumor and provides nutrients and oxygen [ 13 ] . This model is illustrated by the experimental results presented here, as both A549 (lung) and U118 (brain) cell lines are observed to upregulate one set of genetic programs related to cell growth and proliferation when in culture and another set related to cell adhesion, the extracellular matrix, growth substances, and neovascularization when developing as an in vivo tumor.
Some of the fibroblasts differentiate into myofibroblasts, which contract to close the wound [ 4 14 15 ] . Myofibroblasts are fibrogenic, showing elevated expression of interstitial collagens, laminin, FN and TN, and inhibitors of matrix metalloproteinases such as TIMP-1 [ 15 16 17 18 19 ] . Because cCAF is expressed highly in the granulation tissue of wounds in areas where ECM is abundant [ 3 6 11 ] , and it stimulates fibroblasts to differentiate into myofibroblasts [ 4 ] , we investigated whether this chemokine stimulates the production of the four major ECM molecules mentioned above, interstitial Colls I and III, TN and cellular FN.
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