Words similar to metalloproteinases
Example sentences for: metalloproteinases
How can you use “metalloproteinases” in a sentence? Here are some example sentences to help you improve your vocabulary:
Macrophages in RA synovium secrete many inflammatory mediators (IL-1, IL-6, IL-8, tumor necrosis factor-α [TNF-α] and PGE 2 ) and a variety of matrix metalloproteinases, and are thought to play a central role in the inflammation and joint destruction characteristic of RA [ 2].
A further degree of regulation of MMP activity is afforded by the family of inhibitors: tissue inhibitors of metalloproteinases (TIMPs) [ 28].
The internal elastic lamella of arteries is shown to form gaps prior to vessel dilatation in an experimental arteriovenous model in rabbit carotid artery [ 2 ] . Collagenase and matrix metalloproteinases (MMPs) have been observed to be upregulated during vessel dilation either in flow-induced model [ 10 ] or in a post-stenotic dilatation [ 11 ] .
For instance, IL-1-degraded cartilage tissues and cell suspensions are frequently employed as model systems to study cartilage metabolism under osteoarthritis-like conditions [ 1 2 3 4 ] and to assess the efficacy of various drug therapies [ 5 6 7 8 9 ] . IL-1 signals cells via cell surface receptors to upregulate proteases, matrix metalloproteinases and aggrecanase, while downregulating matrix metalloproteinase inhibition and proteoglycan synthesis [ 10 11 ] . The ultimate effect of these metabolic changes include damage to the ECM, loss of ECM components (especially proteoglycan), and alteration of the normal balance of catabolic and anabolic processes that regulate cartilage ECM composition.
This example illustrates how functional relationships that could not be deduced from gene names were uncovered through the analysis of patterns of term occurrence: matrix metalloproteinases (MMP1, 10, 14) and urokinase plasminogen activator (UPA, SPARC) are matrix-interacting molecules involved in tumor invasion and metastasis.
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