Words similar to metalloproteinases
Example sentences for: metalloproteinases
How can you use “metalloproteinases” in a sentence? Here are some example sentences to help you improve your vocabulary:
Macrophages in RA synovium secrete many inflammatory mediators (IL-1, IL-6, IL-8, tumor necrosis factor-α [TNF-α] and PGE 2 ) and a variety of matrix metalloproteinases, and are thought to play a central role in the inflammation and joint destruction characteristic of RA [ 2].
A further degree of regulation of MMP activity is afforded by the family of inhibitors: tissue inhibitors of metalloproteinases (TIMPs) [ 28].
These compounds may have played a role in the inhibitory effect observed, probably owing to the chelation of the zinc required for the catalytic activity of venom's haemorrhagic metalloproteinases [ 45 ] . Reduction in the intensity of the effects of envenomation could also be achieved by a neutralisation of the venom peptides, polypeptides, proteins and enzymes [ 38 11 ] . There are plants used for snakebite that act by inhibiting the proteolytic activities of the venom and antagonising crotoxin-induced haemolysis, myotoxic and haemorrhagic activities of crotalid venoms [ 46 ] .
Our previous work has focused on the pathways by which IL-1β induces several members of the family of matrix metalloproteinases (MMPs), enzymes that are active at neutral pH and that collectively degrade the various components of the extracellular matrix.
Some of the fibroblasts differentiate into myofibroblasts, which contract to close the wound [ 4 14 15 ] . Myofibroblasts are fibrogenic, showing elevated expression of interstitial collagens, laminin, FN and TN, and inhibitors of matrix metalloproteinases such as TIMP-1 [ 15 16 17 18 19 ] . Because cCAF is expressed highly in the granulation tissue of wounds in areas where ECM is abundant [ 3 6 11 ] , and it stimulates fibroblasts to differentiate into myofibroblasts [ 4 ] , we investigated whether this chemokine stimulates the production of the four major ECM molecules mentioned above, interstitial Colls I and III, TN and cellular FN.
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