Words similar to metalloproteinases
Example sentences for: metalloproteinases
How can you use “metalloproteinases” in a sentence? Here are some example sentences to help you improve your vocabulary:
In addition, chondrocytes produce enzymes, such as the matrix metalloproteinases (MMPs), that degrade the cartilage [ 2 ] . In arthritis, an imbalance of these processes in favour of degradation results in a loss of cartilage.
Some of the fibroblasts differentiate into myofibroblasts, which contract to close the wound [ 4 14 15 ] . Myofibroblasts are fibrogenic, showing elevated expression of interstitial collagens, laminin, FN and TN, and inhibitors of matrix metalloproteinases such as TIMP-1 [ 15 16 17 18 19 ] . Because cCAF is expressed highly in the granulation tissue of wounds in areas where ECM is abundant [ 3 6 11 ] , and it stimulates fibroblasts to differentiate into myofibroblasts [ 4 ] , we investigated whether this chemokine stimulates the production of the four major ECM molecules mentioned above, interstitial Colls I and III, TN and cellular FN.
Ultimately, the integral cell-surface metalloproteinases ADAM-10 and ADAM-17/TACE were found to underlie α-secretase-type ectodomain shedding [3,46].
EC, endothelial cell; MMP, matrix metalloproteinases; 3D, three-dimensional; KDR, kinase domain receptor; SSHDD, suppression subtractive hybridization followed by differential display; VE-cadherin, vascular endothelial-cadherin; PMA, phorbol 12-myristate 13-acetate; VEGF, vascular endothelial growth factor; bFGF, basic fibroblast growth factor.
For instance, IL-1-degraded cartilage tissues and cell suspensions are frequently employed as model systems to study cartilage metabolism under osteoarthritis-like conditions [ 1 2 3 4 ] and to assess the efficacy of various drug therapies [ 5 6 7 8 9 ] . IL-1 signals cells via cell surface receptors to upregulate proteases, matrix metalloproteinases and aggrecanase, while downregulating matrix metalloproteinase inhibition and proteoglycan synthesis [ 10 11 ] . The ultimate effect of these metabolic changes include damage to the ECM, loss of ECM components (especially proteoglycan), and alteration of the normal balance of catabolic and anabolic processes that regulate cartilage ECM composition.
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