Example sentences for: metalloproteinase-

How can you use “metalloproteinase-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Primer sets were designed for 6 of the 13 genes; matrix metalloproteinase-9 (MMP-9), thrombospondin-1 (TSP-1), CD24, defensin α3, lipocalin-2 (LNC2), and lactoferrrin (see Table 2).

  • AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; DMEM, Dulbecco's modified Eagle medium; FBS, fetal bovine serum certified; FCC, ferricytochrome c type III; HBSS, Hank's balanced salt solution; LPS, lipopolysaccharide; MMP-9, matrix metalloproteinase-9; O 2 -, superoxide; P, penicillin; PBS, phosphate buffered saline; PMA, phorbol 12-myristate 13-acetate ; RT-PCR, reverse transcriptase polymerase chain reaction; S, streptomycin; SOD, superoxide dismutase; TNF-α, tumor necrosis factor.

  • Other genes in cluster A are involved in tissue remodeling (those encoding tissue inhibitor of metalloproteinase-1 (TIMP-1) [ 23], plasminogen activator inhibitor-1 (PAI-1) [ 24], and chitinase [ 25, 26]) or in wound healing (tumor-associated antigen L6).

  • In addition, IL-4 inhibits growth factor-induced RA synoviocyte proliferation, and expression of prostaglandin E and matrix metalloproteinase-3 in RA synovial fibroblast [ 14, 15, 16], and reduces bone resorption.

  • A recent study confirms this to be the case in breast cancer, where expression of TSP-1 in stroma adjacent to ductal carcinoma in situ is lost in cases with more aggressive histological features [ 30 ] . There are also reports, however, that fibroblast TSP-1 can induce matrix metalloproteinase-9 in breast tumor cells and gastric cancer tumor cells, and this in turn may lead to a more invasive phenotype [ 14 31 ] . In the present study, TSP-1 was not expressed differentially in the stroma of benign tissue specimens or malignant tissue specimens, nor in the epithelial component of breast tumors with or without metastases.


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